6-Chloro-5-nitropicolinic acid

Base Information

• Chemical Name: 6-Chloro-5-nitropicolinic acid
• CAS No.: 353277-27-7
• Molecular Formula: C6H3ClN2O4
• Molecular Weight: 202.554
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10361038
• Wikidata: Q82143131
• Mol file: 353277-27-7.mol

Synonyms:6-Chloro-5-nitropicolinic acid;353277-27-7;6-chloro-5-nitropyridine-2-carboxylic acid;MFCD01927937;6-Chloro-5-nitropicolinicacid;SCHEMBL805289;AMY2011;DTXSID10361038;AKOS016012810;CS-W006408;DS-5471;SY109252;FT-0701619;EN300-110367;A874633;6-Chloro-5-nitropyridine-2-carboxylic acid

Chemical Property of 6-Chloro-5-nitropicolinic acid

Chemical Property:

• Boiling Point: 413.6±45.0 °C(Predicted)
• PKA: 2.34±0.13(Predicted)
• PSA: 96.01000
• Density: 1.702±0.06 g/cm3(Predicted)
• LogP: 1.86460
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 201.9781343
• Heavy Atom Count: 13
• Complexity: 229

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Chloro-5-nitropicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1[N+](=O)[O-])Cl)C(=O)O

Technology Process of 6-Chloro-5-nitropicolinic acid

There total 4 articles about 6-Chloro-5-nitropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-6-methyl-3-nitropyridine (56057-19-3) → 6-chloro-5-nitropyridine-2-carboxylic acid (353277-27-7)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; at 15 - 50 ℃; for 20h;

Reference yield:

6-amino-5-nitro-2-picoline (21901-29-1) → 6-chloro-5-nitropyridine-2-carboxylic acid (353277-27-7)

Guidance literature:

Multi-step reaction with 3 steps

1: water; sodium nitrite; sulfuric acid / 16 h / 0 °C

2: trichlorophosphate / 4 h / Reflux

3: sodium dichromate; sulfuric acid / 40 h / 30 °C

With sodium dichromate; sulfuric acid; water; sodium nitrite; trichlorophosphate;

Reference yield:

6-methyl-3-nitrohydropyridin-2-one (39745-39-6) → 6-chloro-5-nitropyridine-2-carboxylic acid (353277-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 4 h / Reflux

2: sodium dichromate; sulfuric acid / 40 h / 30 °C

With sodium dichromate; sulfuric acid; trichlorophosphate;

upstream raw materials:

6-amino-5-nitro-2-picoline

6-methyl-3-nitrohydropyridin-2-one

2-Amino-6-methylpyridine

2-chloro-6-methyl-3-nitropyridine

Downstream raw materials:

5-nitro-6-phenylmethoxypyridine-2-carboxylic acid

6-amino-5-nitro-pyridine-2-carboxylic acid methyl ester

6-amino-5-nitropyridine-2-carboxylic acid

6-methoxy-5-nitropicolinic acid

Refernces

• 1、 -. "GLP-1R AGONISTS AND USES THEREOF". Page/Page column 59; 70; 71. . Retrieved 2020/10/21.
• 2、 -. "AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS". Page/Page column 114; 158. . Retrieved 2016/11/17.