3,4-Dimethoxy-α-hydroxybenzeneacetic acid methyl ester

Base Information

• Chemical Name: 3,4-Dimethoxy-α-hydroxybenzeneacetic acid methyl ester
• CAS No.: 2911-73-1
• Molecular Formula: C11H14O5
• Molecular Weight: 226.229
• Mol file: 2911-73-1.mol

Synonyms:3,4-Dimethoxy-α-hydroxybenzeneacetic acid methyl ester

Chemical Property of 3,4-Dimethoxy-α-hydroxybenzeneacetic acid methyl ester

Chemical Property:

• Boiling Point: 104-105 °C(Press: 750 Torr)
• PKA: 12.01±0.20(Predicted)
• Density: 1.200±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-Dimethoxy-α-hydroxybenzeneacetic acid methyl ester

There total 7 articles about 3,4-Dimethoxy-α-hydroxybenzeneacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methanol (67-56-1) + 3,4-dimethoxy-benzaldehyde (120-14-9) + 2-hydroxypropanedinitrile (20342-65-8) → α-hydroxy-3,4-dimethoxyphenylacetic acid methyl ester (2911-73-1)

Guidance literature:

With dmap; trifluoroacetic acid; at 20 ℃; for 0.666667h;

Reference yield: 57.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3,4-dimethoxyphenylglycolic acid (13443-54-4) → α-hydroxy-3,4-dimethoxyphenylacetic acid methyl ester (2911-73-1)

Guidance literature:

In diethyl ether; for 16h;

Reference yield:

C11H15NO4*ClH (94582-71-5) → α-hydroxy-3,4-dimethoxyphenylacetic acid methyl ester (2911-73-1)

Guidance literature:

With water; In dichloromethane; for 1h;

upstream raw materials:

diazomethane

3,4-dimethoxyphenylglycolic acid

3,4-dimethoxy-benzaldehyde

C₁₁H₁₅NO₄*ClH

Downstream raw materials:

3,4-dimethoxyphenylglycolic acid

benzyl 2-chloro-2-(3,4-dimethoxyphenyl)acetate

benzyl 2-(3,4-dimethoxyphenyl)-2-hydroxyacetate

veraguensin

Refernces

• 1、 Liu, Yidong,Liu, Song,Li, Dongmei,Zhang, Nan,Peng, Lei,Ao, Jun,Song, Choong Eui,Lan, Yu,Yan, Hailong. "Kinetic Resolution of Allylic Alcohol with Chiral BINOL-Based Alkoxides: A Combination of Experimental and Theoretical Studies". . p. 1150 - 1159. Retrieved 2019/01/11.
• 2、 -. "2-(ARYLOXY)ACETAMIDE FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS". . . Retrieved 2008/06/13.