Imidazo[1,5-a]pyrazine-7(1H)-carboxylic acid, hexahydro-3-oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Imidazo[1,5-a]pyrazine-7(1H)-carboxylic acid, hexahydro-3-oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester
• CAS No.: 1256815-88-9
• Molecular Formula: C₁₈H₂₅N₃O₃
• Molecular Weight: 0
• Mol file: 1256815-88-9.mol

Synonyms:Imidazo[1,5-a]pyrazine-7(1H)-carboxylic acid, hexahydro-3-oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester

Chemical Property of Imidazo[1,5-a]pyrazine-7(1H)-carboxylic acid, hexahydro-3-oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

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Technology Process of Imidazo[1,5-a]pyrazine-7(1H)-carboxylic acid, hexahydro-3-oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester

There total 5 articles about Imidazo[1,5-a]pyrazine-7(1H)-carboxylic acid, hexahydro-3-oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

tert-butyl 3-oxo-1,2,5,6,8,8a-hexahydroimidazo[1,5-a]pyrazine-7-carboxylate (1246551-25-6) + benzyl bromide (100-39-0) → tert-butyl 2-benzylhexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate (1256815-88-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; Reflux;

DOI:10.1080/00397911.2010.525774

Reference yield:

tert-butyl 3-oxo-1,2,5,6,8,8a-hexahydroimidazo[1,5-a]pyrazine-7-carboxylate (1246551-25-6) → tert-butyl 2-benzylhexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate (1256815-88-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; Reflux;

DOI:10.1016/j.ejmech.2010.08.002

Reference yield:

di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate (1256815-06-1) → tert-butyl 2-benzylhexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate (1256815-88-9)

Guidance literature:

Multi-step reaction with 3 steps

1: methylamine / ethanol / 4 h / Reflux

2: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Reflux

3: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Reflux

With sodium hydride; methylamine; In tetrahydrofuran; ethanol; mineral oil; 1: Mitsunobu reaction;

DOI:10.1080/00397911.2010.525774

upstream raw materials:

tert-butyl 3-oxo-1,2,5,6,8,8a-hexahydroimidazo[1,5-a]pyrazine-7-carboxylate

di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate

di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate

benzyl bromide

Downstream raw materials:

2-benzylhexahydroimidazo[1,5-a]pyrazin-3(2H)-one

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