8-chloro-3-methoxy-1,7-Naphthyridine

Base Information

• Chemical Name: 8-chloro-3-methoxy-1,7-Naphthyridine
• CAS No.: 1600511-75-8
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.62
• Mol file: 1600511-75-8.mol

Synonyms:8-chloro-3-methoxy-1,7-Naphthyridine

Chemical Property of 8-chloro-3-methoxy-1,7-Naphthyridine

Chemical Property:

• PSA: 35.01000
• LogP: 2.29180

Purity/Quality:

97% ^*data from raw suppliers

8-Chloro-3-methoxy-1,7-naphthyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-chloro-3-methoxy-1,7-Naphthyridine

There total 13 articles about 8-chloro-3-methoxy-1,7-Naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Cyano-3,5-dichloropyridine (85331-33-5) → 8-chloro-3-methoxy-1,7-naphthyridine (1600511-75-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 0.58 h / 0 - 20 °C

1.2: 0.42 h / 20 °C / Sealed tube

1.3: 3 h / 90 °C / Sealed tube

2.1: sodium methylate / 2 h / 55 °C

3.1: sodium carbonate; dihydrogen peroxide / water; acetone / 2 h / 20 °C

4.1: toluene-4-sulfonic acid / toluene / 20 h / Reflux

5.1: trichlorophosphate / acetonitrile / 5 h / 85 °C

With dihydrogen peroxide; sodium methylate; sodium carbonate; toluene-4-sulfonic acid; trichlorophosphate; In water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;

Reference yield:

3-methoxy-1,7-naphthyridin-8(7H)-one (1569695-13-1) → 8-chloro-3-methoxy-1,7-naphthyridine (1600511-75-8)

Guidance literature:

With trichlorophosphate; In acetonitrile;

Reference yield:

8-chloro-1,7-naphthyridin-3-ol (1620981-38-5) + methyl iodide (74-88-4) → 8-chloro-3-methoxy-1,7-naphthyridine (1600511-75-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

5-methoxy-3-((triethylsilyl)ethynyl)picolinonitrile

3-(2,2-dimethoxyethyl)-5-methoxypicolinonitrile

3-(2,2-dimethoxyethyl)-5-methoxypicolinamide

3-methoxy-1,7-naphthyridin-8(7H)-one

Downstream raw materials:

3-Methoxy-N-(4-methoxybenzyl)-1,7-naphthyridin-8-amine

(2S,3R)-5-Amino-2-fluoro-3-(2-fluoro-5-((3-methoxy-1,7-naphthyridin-8-yl)amino)phenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

tert-butyl ((5R,6S)-6-fluoro-5-(2-fluoro-5-((3-methoxy-1,7-naphthyridin-8-yl)amino)phenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate

N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-3-methoxy-1,7-naphthyridin-8-amine