Technology Process of 8-chloro-1,7-naphthyridin-3-ol
There total 1 articles about 8-chloro-1,7-naphthyridin-3-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N,N-dimethyl-formamide / 0.58 h / 0 - 20 °C
1.2: 3 h / 90 °C / Sealed tube; Inert atmosphere
2.1: sodium methylate / methanol / 2 h / 55 °C / Sealed tube
3.1: dihydrogen peroxide; sodium carbonate / water; acetone / 2 h / 20 °C
4.1: toluene-4-sulfonic acid / toluene / 20 h / Reflux
5.1: trichlorophosphate / acetonitrile / 5 h / 85 °C
6.1: boron trichloride; tetra-(n-butyl)ammonium iodide / dichloromethane / 5 h / 20 °C
With
dihydrogen peroxide; sodium methylate; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium carbonate; toluene-4-sulfonic acid; trichlorophosphate;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: trimethylsilyl bromide / acetonitrile / 16 h / 80 °C
3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxyethane / 1 h / 65 °C / Inert atmosphere
3.2: 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); trimethylsilyl bromide; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,2-dimethoxyethane; N,N-dimethyl-formamide; acetonitrile;
