L-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-diMethylpropyl)-, (3R,4S,5R)-

Base Information

Chemical Name:L-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-diMethylpropyl)-, (3R,4S,5R)-
CAS No.:1219089-32-3
Molecular Formula:C23H22Cl2F2N2O2
Molecular Weight:467.3357864
Hs Code.:
Mol file:1219089-32-3.mol

Synonyms:L-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-diMethylpropyl)-, (3R,4S,5R)-

Suppliers and Price of L-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-diMethylpropyl)-, (3R,4S,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ChemScene
L-Proline,3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-,(3R,4S,5R)-
100mg
$ 750.00

Total 4 raw suppliers

Chemical Property of L-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-diMethylpropyl)-, (3R,4S,5R)-

Chemical Property:

PSA：73.12000
LogP:6.00678

Purity/Quality:

≥95% ^*data from raw suppliers

L-Proline,3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-,(3R,4S,5R)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of L-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-diMethylpropyl)-, (3R,4S,5R)-

There total 10 articles about L-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-diMethylpropyl)-, (3R,4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: racemic (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acid trifluoroacetic acid salt

: 1219089-31-2
(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acid

: 1219089-32-3
(2S,3R,4S,5R)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acid

Guidance literature:: In methanol; at 30 ℃; under 75007.5 Torr;
DOI:10.1021/jm400487c

Reference yield: 12.0%

: 1219086-88-0
tert-butyl (2S,3R,4S,5R)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylate

: 1219089-32-3
(2S,3R,4S,5R)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acid

Guidance literature:: With trifluoroacetic acid; at 25 ℃; for 8h;

Reference yield:

: 75279-53-7
2-(4-chloro-2-fluoro-phenyl)acetonitrile

: 1219089-32-3
(2S,3R,4S,5R)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate; methanol / 12 h / 45 °C

2.1: triethylamine; silver fluoride / dichloromethane / 18 h / 25 °C

2.2: 2 h / 100 °C

3.1: trifluoroacetic acid / 8 h / 25 °C

With methanol; sodium methylate; silver fluoride; triethylamine; trifluoroacetic acid; In dichloromethane;