2-chloro-N-(2-fluoro-5-nitrophenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(2-fluoro-5-nitrophenyl)acetamide
• CAS No.: 379254-83-8
• Molecular Formula: C8H6ClFN2O3
• Molecular Weight: 232.5962432
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID10368481
• Wikidata: Q82155045
• Mol file: 379254-83-8.mol

Synonyms:2-chloro-N-(2-fluoro-5-nitrophenyl)acetamide;379254-83-8;SCHEMBL3207417;DTXSID10368481;MFCD02799328;AKOS001073516;AS-40357;CS-0307540;EN300-01766;A873980;Z56862357

Chemical Property of 2-chloro-N-(2-fluoro-5-nitrophenyl)acetamide

Chemical Property:

• PSA: 78.41000
• LogP: 3.08390
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 232.0050979
• Heavy Atom Count: 15
• Complexity: 259

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-N-(2-fluoro-5-nitrophenyl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1[N+](=O)[O-])NC(=O)CCl)F

Technology Process of 2-chloro-N-(2-fluoro-5-nitrophenyl)acetamide

There total 1 articles about 2-chloro-N-(2-fluoro-5-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-fluoro-3-nitroaniline (369-36-8) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(2-fluoro-5-nitrophenyl)acetamide (379254-83-8)

Guidance literature:

In acetone; at 20 ℃; for 1h;

DOI:10.1039/b109725c

Reference yield:

methylamine (74-89-5) + 2-chloro-N-(2-fluoro-5-nitrophenyl)acetamide (379254-83-8) → C9H10FN3O3

Guidance literature:

In ethanol; at 20 ℃; for 2h;

DOI:10.1371/journal.pone.0085706

Reference yield:

methylamine (74-89-5) + 2-chloro-N-(2-fluoro-5-nitrophenyl)acetamide (379254-83-8) → N2-Chloracetyl-N1-methyl-4-nitro-o-phenylendiamin (90346-93-3)

Guidance literature:

In ethanol; at 20 ℃; for 2h;

DOI:10.1371/journal.pone.0085706

upstream raw materials:

6-fluoro-3-nitroaniline

chloroacetyl chloride

Downstream raw materials:

2'-fluoro-5'-nitro-2-piperidinoacetanilide

2'-fluoro-5'-nitro-2-[2-(1,2,3,4-tetrahydroisoquinolinolyl)]acetanilide

6-nitro-1-methyl-6-nitroquinoxaline-2,3(1H,4H)-dione

N²-Chloracetyl-N¹-methyl-4-nitro-o-phenylendiamin