3-Bromofuro[3,4-b]pyridine-5,7-dione

Base Information

• Chemical Name: 3-Bromofuro[3,4-b]pyridine-5,7-dione
• CAS No.: 98278-78-5
• Molecular Formula: C7H2BrNO3
• Molecular Weight: 228.002
• Hs Code.: 2934999090
• European Community (EC) Number: 832-197-1
• Mol file: 98278-78-5.mol

Synonyms:98278-78-5;3-bromofuro[3,4-b]pyridine-5,7-dione;5-BROMO-2,3-PYRIDINEDICARBOXYLIC ANHYDRIDE;3-BROMO-5H,7H-FURO[3,4-B]PYRIDINE-5,7-DIONE;3-BROMO-FURO[3,4-B]PYRIDINE-5,7-DIONE;C7H2BrNO3;SCHEMBL4073817;FMIBWNJUQJRTER-UHFFFAOYSA-N;YDA27878;MFCD16250351;AKOS005266415;PB24218;AS-34899;CS-0051464;EN300-304651;A858562

Chemical Property of 3-Bromofuro[3,4-b]pyridine-5,7-dione

Chemical Property:

• Melting Point: 137-140 °C
• Boiling Point: 385.4±27.0 °C(Predicted)
• PKA: -4.60±0.20(Predicted)
• PSA: 56.26000
• Density: 2.036±0.06 g/cm3(Predicted)
• LogP: 1.15470
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 226.92181
• Heavy Atom Count: 12
• Complexity: 243

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2,3-pyridinecarboxylicAnhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC2=C1C(=O)OC2=O)Br

Technology Process of 3-Bromofuro[3,4-b]pyridine-5,7-dione

There total 1 articles about 3-Bromofuro[3,4-b]pyridine-5,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-Bromo-pyridine-2,3-dicarboxylic acid (98555-51-2) → 3-bromofuro[3,4-b]pyridine-5,7-dione (98278-78-5)

Guidance literature:

With acetic anhydride; at 80 ℃; for 2h;

DOI:10.1016/j.bmcl.2017.05.048

Reference yield: 67.0%

3-bromofuro[3,4-b]pyridine-5,7-dione (98278-78-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3-benzoyl-5-bromopyridine-2-carboxylic acid (96464-20-9)

Guidance literature:

With aluminum (III) chloride; In nitrobenzene; at 85 ℃; for 17h; Cooling with ice;

DOI:10.1016/j.bmcl.2017.05.048

Reference yield:

3-bromofuro[3,4-b]pyridine-5,7-dione (98278-78-5) + diethylamine (109-89-7) → 5-bromo-N,N-diethylnicotinamide (104290-44-0)

Guidance literature:

upstream raw materials:

5-Bromo-pyridine-2,3-dicarboxylic acid

Downstream raw materials:

5-bromo-N,N-diethylnicotinamide

3-benzoyl-5-bromopyridine-2-carboxylic acid