5-BROMO-N,N-DIETHYL-3-PYRIDINECARBOXAMIDE

Base Information

• Chemical Name: 5-BROMO-N,N-DIETHYL-3-PYRIDINECARBOXAMIDE
• CAS No.: 104290-44-0
• Molecular Formula: C10H13BrN2O
• Molecular Weight: 257.13
• Hs Code.: 2933399090
• Mol file: 104290-44-0.mol

Synonyms:5-Brom-nicotinsaeure-diaethylamid;5-bromo-nicotinic acid diethylamide;3-Pyridinecarboxamide,5-bromo-N,N-diethyl;5-bromo-N,N-diethylnicotinamide;

Chemical Property of 5-BROMO-N,N-DIETHYL-3-PYRIDINECARBOXAMIDE

Chemical Property:

• PSA: 33.20000
• LogP: 2.32610
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-N,N-diethylnicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-N,N-DIETHYL-3-PYRIDINECARBOXAMIDE

There total 6 articles about 5-BROMO-N,N-DIETHYL-3-PYRIDINECARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-bromonicotinoyl chloride (39620-02-5) + diethylamine (109-89-7) → 5-bromo-N,N-diethylnicotinamide (104290-44-0)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 20 ℃; Inert atmosphere;

DOI:10.1039/c5ob00430f

Reference yield:

5-bromo-3-pyridinecarboxylic acid (20826-04-4) + diethylamine (109-89-7) → 5-bromo-N,N-diethylnicotinamide (104290-44-0)

Guidance literature:

5-bromo-3-pyridinecarboxylic acid; With thionyl chloride; at 0 ℃; for 3h; Reflux;

diethylamine; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

5-bromo-3-pyridinecarboxylic acid (20826-04-4) → 5-bromo-N,N-diethylnicotinamide (104290-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

With thionyl chloride; 1: Substitution / 2: Substitution;

DOI:10.1002/(SICI)1096-9063(199708)50:4<275::AID-PS593>3.0.CO;2-7

upstream raw materials:

5-bromonicotinoyl chloride

diethylamine

3-bromofuro[3,4-b]pyridine-5,7-dione

5-bromo-3-pyridinecarboxylic acid

Refernces

• 1、 Knight, Brian J.,Tolchin, Zachary A.,Smith, Joel M.. "A predictive model for additions to: N -alkyl pyridiniums". supporting information. p. 2693 - 2696. Retrieved 2021/03/18.
• 2、 Pan, Xiaoyan,Dong, Jinyun,Shi, Yaling,Shao, Ruili,Wei, Fen,Wang, Jinfeng,Zhang, Jie. "Discovery of novel Bcr-Abl inhibitors with diacylated piperazine as the flexible linker". . p. 7050 - 7066. Retrieved 2015/06/25.