[1,1'-Biphenyl]-4-MethanaMine, N,N-diMethyl-

Base Information

• Chemical Name: [1,1'-Biphenyl]-4-MethanaMine, N,N-diMethyl-
• CAS No.: 127292-60-8
• Molecular Formula: C15H17N
• Molecular Weight: 211.307
• Mol file: 127292-60-8.mol

Synonyms:[1,1'-Biphenyl]-4-MethanaMine, N,N-diMethyl-;N,N-dimethyl-[1,1'-Biphenyl]-4-methanamine

Chemical Property of [1,1'-Biphenyl]-4-MethanaMine, N,N-diMethyl-

Chemical Property:

• Boiling Point: 112-114 °C(Press: 0.02 Torr)
• PKA: 8.69±0.28(Predicted)
• PSA: 3.24000
• Density: 1.000±0.06 g/cm3(Predicted)
• LogP: 3.41520

Purity/Quality:

97% ^*data from raw suppliers

BIPHENYL-4-YLMETHYL-DIMETHYL-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1,1'-Biphenyl]-4-MethanaMine, N,N-diMethyl-

There total 13 articles about [1,1'-Biphenyl]-4-MethanaMine, N,N-diMethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(fluoromethyl)-1,1’-biphenyl + N,N-dimethylammonium chloride (506-59-2) → 1-([1,1’-biphenyl]-4-yl)-N,N-dimethylmethanamine (127292-60-8)

Guidance literature:

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In isopropyl alcohol; at 70 ℃; for 18h;

DOI:10.1021/ol400765a

Reference yield: 93.0%

p-phenylbenzyl bromide (2567-29-5) + dimethyl amine (124-40-3) → 1-([1,1’-biphenyl]-4-yl)-N,N-dimethylmethanamine (127292-60-8)

Guidance literature:

In ethanol; at 70 - 75 ℃; for 24h;

DOI:10.1016/j.mencom.2007.03.009

Reference yield: 81.0%

N, N-dimethyl [1,1’-biphenyl]-4-carboxamide (33322-67-7) → 1-([1,1’-biphenyl]-4-yl)-N,N-dimethylmethanamine (127292-60-8)

Guidance literature:

With sodium hydride; zinc(II) chloride; In tetrahydrofuran; mineral oil; at 60 ℃; for 0.25h; Sealed tube;

DOI:10.1002/anie.201900233

upstream raw materials:

(4-bromobenzyl)dimethylamine

phenylboronic acid

p-phenylbenzyl bromide

dimethyl amine

Downstream raw materials:

2-([1,1′-biphenyl]-4-yl)benzo[d]thiazole

4-Phenylbenzaldehyde

4-Methylbiphenyl

(4-biphenylyl)acetic acid