(S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(MethylaMino)propanaMide

Base Information

Chemical Name:(S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(MethylaMino)propanaMide
CAS No.:1005342-47-1
Molecular Formula:C28H35FN4O3
Molecular Weight:494.6009032
Hs Code.:
Mol file:1005342-47-1.mol

Synonyms:(S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(MethylaMino)propanaMide;(S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)pyridin-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(MethylaMino)propanaMide;LCL161 Enantiomer;(4-Fluorophenyl)[5-[(2S)-1-[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl]-2-pyrrolidinyl]-3-pyridinyl]methanone;(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)pyridin-2-yl)pyrrolidin-1-yl)-2-oxoethyl)

Suppliers and Price of (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(MethylaMino)propanaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(MethylaMino)propanaMide

Chemical Property:

PSA：91.40000
LogP:4.50790

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(MethylaMino)propanaMide

There total 10 articles about (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(MethylaMino)propanaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)-pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylaminopropionamide dihydrotrifluoroacetate

: 1005342-47-1
(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; pH=8;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1005342-47-1
(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / hexane; diethyl ether / 1 h / -70 - -65 °C

1.2: 2 h / -70 °C

2.1: Dess-Martin periodane / dichloromethane / 0.33 h / 25 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / -70 - 20 °C

4.1: n-butyllithium / hexane; diethyl ether / -73 - -70 °C

4.2: -73 - -70 °C

5.1: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

6.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 2 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / -20 - 0 °C

8.1: sodium hydrogencarbonate / dichloromethane; water / pH 8

With n-butyllithium; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;

Reference yield:

: 116332-54-8
4-fluoro-N-methoxy-N-methylbenzamide

: 1005342-47-1
(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; diethyl ether / -73 - -70 °C

1.2: -73 - -70 °C

2.1: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / -20 - 0 °C

5.1: sodium hydrogencarbonate / dichloromethane; water / pH 8

With n-butyllithium; sodium hydrogencarbonate; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;