(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide citrate

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Chemical Name:(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide citrate
CAS No.:1005342-48-2
Molecular Formula:C₆H₈O₇*C₂₈H₃₅FN₄O₃
Molecular Weight:686.735
Hs Code.:

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Chemical Property of (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide citrate

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Technology Process of (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide citrate

There total 11 articles about (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide citrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005342-47-1
(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

: 77-92-9,906507-37-7
citric acid

: 1005342-48-2
(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide citrate

Guidance literature:: In water; pH=8;

Reference yield:

: 116332-54-8
4-fluoro-N-methoxy-N-methylbenzamide

: 1005342-48-2
(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide citrate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; diethyl ether / -73 - -70 °C

1.2: -73 - -70 °C

2.1: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / -20 - 0 °C

5.1: sodium hydrogencarbonate / dichloromethane; water / pH 8

6.1: water / pH 8

With n-butyllithium; sodium hydrogencarbonate; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;

Reference yield:

: 1005342-84-6
4-(5-Bromo-pyridin-3-yl)-4-oxo-butyraldehyde

: 1005342-48-2
(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluoro-benzoyl)-pyridin-3-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide citrate

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / -70 - 20 °C

2.1: n-butyllithium / hexane; diethyl ether / -73 - -70 °C

2.2: -73 - -70 °C

3.1: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / -20 - 0 °C

6.1: sodium hydrogencarbonate / dichloromethane; water / pH 8

7.1: water / pH 8

With n-butyllithium; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;