1,4-Piperidinedicarboxylic acid, 4-(2-hydroxyethyl)-, 1-(1,1-diMethylethyl) 4-ethyl ester

Base Information

• Chemical Name: 1,4-Piperidinedicarboxylic acid, 4-(2-hydroxyethyl)-, 1-(1,1-diMethylethyl) 4-ethyl ester
• CAS No.: 247133-32-0
• Molecular Formula: C₁₅H₂₇NO₅
• Molecular Weight: 301.383
• Mol file: 247133-32-0.mol

Synonyms:1,4-Piperidinedicarboxylic acid, 4-(2-hydroxyethyl)-, 1-(1,1-diMethylethyl) 4-ethyl ester;4-(2-Hydroxyethyl)-1,4-Piperidinedicarboxylic Acid 1-(1,1-DiMethylethyl) 4-Ethyl Ester

Chemical Property of 1,4-Piperidinedicarboxylic acid, 4-(2-hydroxyethyl)-, 1-(1,1-diMethylethyl) 4-ethyl ester

Chemical Property:

• Vapor Pressure: 1.03E-07mmHg at 25°C
• Boiling Point: 390.5°C at 760 mmHg
• PKA: 15.10±0.10(Predicted)
• Flash Point: 189.9°C
• PSA: 76.07000
• Density: 1.106g/cm³
• LogP: 1.88710

Purity/Quality:

99% ^*data from raw suppliers

4-(2-Hydroxyethyl)-1,4-PiperidinedicarboxylicAcid1-(1,1-Dimethylethyl)4-EthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(2-Hydroxyethyl)-1,4-Piperidinedicarboxylic Acid 1-(1,1-Dimethylethyl) 4-Ethyl Ester, is a piperidine derivative.

Technology Process of 1,4-Piperidinedicarboxylic acid, 4-(2-hydroxyethyl)-, 1-(1,1-diMethylethyl) 4-ethyl ester

There total 3 articles about 1,4-Piperidinedicarboxylic acid, 4-(2-hydroxyethyl)-, 1-(1,1-diMethylethyl) 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tert-butoxycarbonyl-4-ethoxycarbonylpiperidin-4-ylacetic acid (247133-31-9) + borane tetrahydrofuran → 4-ethoxycarbonyl-4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester (247133-32-0)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water;

Reference yield:

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate (146603-99-8) → 4-ethoxycarbonyl-4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester (247133-32-0)

Guidance literature:

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate; With ozone; In methanol; dichloromethane; at -78 ℃;

With sodium tetrahydroborate; at -78 - 20 ℃; for 3h;

DOI:10.1016/S0960-894X(02)00250-0

Reference yield:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) → 4-ethoxycarbonyl-4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester (247133-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: KHMDS / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / 1 h / -78 °C

2.1: O₃ / methanol; CH₂Cl₂ / -78 °C

2.2: NaBH₄ / 3 h / -78 - 20 °C

With potassium hexamethylsilazane; ozone; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0960-894X(02)00250-0

upstream raw materials:

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

1-tert-butoxycarbonyl-4-ethoxycarbonylpiperidin-4-ylacetic acid

Downstream raw materials:

1,1-dimethylethyl 1-oxo-2-oxa-8-azaspiro[4,5]decane-8-carboxylate

2-oxa-8-aza-spiro[4.5]decan-1-one

2-oxa-8-azaspiro[4.5]decane

1,1-dimethylethyl 2-oxa-8-azaspiro[4,5]decane-8-carboxylate