10,11-Dihydro-N-(2-hydroxyethyl)-N-methyl-5H-pyrido[2,3-c][2]benzazepine-10-carboxamide

Base Information

• Chemical Name: 10,11-Dihydro-N-(2-hydroxyethyl)-N-methyl-5H-pyrido[2,3-c][2]benzazepine-10-carboxamide
• CAS No.: 1071504-81-8
• Molecular Formula: C17H19N3O2
• Molecular Weight: 297.357
• Mol file: 1071504-81-8.mol

Synonyms:10,11-Dihydro-N-(2-hydroxyethyl)-N-methyl-5H-pyrido[2,3-c][2]benzazepine-10-carboxamide

Chemical Property of 10,11-Dihydro-N-(2-hydroxyethyl)-N-methyl-5H-pyrido[2,3-c][2]benzazepine-10-carboxamide

Chemical Property:

• PSA: 65.46000
• LogP: 1.72770
• Solubility.: DMSO

Purity/Quality:

97% ^*data from raw suppliers

10,11-Dihydro-N-(2-hydroxyethyl)-N-methyl-5H-pyrido[2,3-c][2]benzazepine-10-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10,11-Dihydro-N-(2-hydroxyethyl)-N-methyl-5H-pyrido[2,3-c][2]benzazepine-10-carboxamide

There total 3 articles about 10,11-Dihydro-N-(2-hydroxyethyl)-N-methyl-5H-pyrido[2,3-c][2]benzazepine-10-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxylic acid ethyl ester (1071504-75-0,1071504-73-8,1071504-74-9) → N-(2-hydroxyethyl)-N-methyl-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxamide (1071504-81-8)

Guidance literature:

at 20 - 70 ℃; for 120.24h; Product distribution / selectivity;

Reference yield: 57.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxylic acid methyl ester (1071504-70-5,1071504-71-6) → N-(2-hydroxyethyl)-N-methyl-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxamide (1071504-81-8)

Guidance literature:

In tetrahydrofuran; at 20 - 75 ℃; for 72.48h; Product distribution / selectivity;

Reference yield:

2-amino-3-benzylpyridine (130277-16-6) → N-(2-hydroxyethyl)-N-methyl-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxamide (1071504-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 0.5 h / 20 °C

2: 110.25 h / 20 - 70 °C

sulfuric acid;

upstream raw materials:

(2-hydroxyethyl)(methyl)amine

10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxylic acid methyl ester

10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxylic acid ethyl ester

2-amino-3-benzylpyridine

Downstream raw materials:

3,4,10,14b-tetrahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepin-1(2H)-one

Mirtazapine

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