Mirin

Base Information

Chemical Name:Mirin
CAS No.:299953-00-7
Molecular Formula:C10H8N2O2S
Molecular Weight:220.25
Hs Code.:2934999090
Mol file:299953-00-7.mol

Synonyms:5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one;MRN-ATM Pathway Inhibitor, Mirin;(5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one

Suppliers and Price of Mirin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
25mg
$ 65.00

TRC
(5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
250mg
$ 350.00

Sigma-Aldrich
MRN-ATM Pathway Inhibitor, Mirin
10mg
$ 135.00

Sigma-Aldrich
Mirin ≥98% (HPLC), powder
25mg
$ 285.00

Sigma-Aldrich
Mirin ≥98% (HPLC), powder
5mg
$ 69.50

Matrix Scientific
(5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one 95+%
2.500g
$ 980.00

Matrix Scientific
(5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one 95+%
1g
$ 449.00

Cayman Chemical
Mirin ≥95%
10mg
$ 55.00

Cayman Chemical
Mirin ≥95%
5mg
$ 29.00

Cayman Chemical
Mirin ≥95%
50mg
$ 232.00

Total 4 raw suppliers

Chemical Property of Mirin

Chemical Property:

PSA：98.48000
LogP:1.95940
Storage Temp.:2-8°C
Sensitive.:Moisture Sensitive
Solubility.:DMSO: >10mg/mL

Purity/Quality:

97% ^*data from raw suppliers

(5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Description Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex, which functions as a DNA damage sensor and activates the DNA repair enzyme ataxia-telangiectasia mutated kinase (ATM). It inhibits phosphorylation of H2AX induced by DNA containing dsDNA breaks (DSBs), indicating decreased ATM activation, with an IC50 value of 66 μM in X. laevis cell-free extracts. Mirin (100 μM) also inhibits the exonuclease activity of Mre11 in a cell-free assay. It induces cell cycle arrest at the G2 phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner. Nanoparticle-encapsulated mirin (50 mg/kg) reduces tumor growth in an LA-N-5 mouse xenograft model.
Uses The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage.[Cayman Chemical] Mirin has been used:as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiationas Mre11 inhibitior in BSC-1 cells infected with simian virus 40in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)

Technology Process of Mirin

There total 1 articles about Mirin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%