(2S,4R)-1-(tert-butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicacid

Base Information

• Chemical Name: (2S,4R)-1-(tert-butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicacid
• CAS No.: 1315326-78-3
• Molecular Formula: C29H31N3O7
• Molecular Weight: 533.57
• Mol file: 1315326-78-3 .mol

Synonyms:(2S,4R)-1-(tert-butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicacid

Chemical Property of (2S,4R)-1-(tert-butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicacid

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(2S,4R)-1-(tert-Butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

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Useful:

Technology Process of (2S,4R)-1-(tert-butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicacid

There total 6 articles about (2S,4R)-1-(tert-butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidine (1315326-77-2) + (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (13726-69-7,946610-68-0) → (2S,4R)-1-(tert-butoxycarbonyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxylic acid (1315326-78-3)

Guidance literature:

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid; With sodium t-butanolate; In dimethylsulfoxide-d6; at 0 - 20 ℃; for 2h;

4-chloro-2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidine; In dimethyl sulfoxide; at 20 ℃; for 1h;

With hydrogenchloride; In water; dimethyl sulfoxide; pH=~ 3;

Reference yield:

salicylonitrile (611-20-1) → (2S,4R)-1-(tert-butoxycarbonyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxylic acid (1315326-78-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

1.2: 3 h / 80 °C

2.1: potassium tert-butylate / tert-butyl alcohol / 3 h / 80 °C

3.1: pyridine / tetrahydrofuran / 0 - 20 °C

4.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C

4.2: pH ~ 2

5.1: trichlorophosphate / 1,4-dioxane / 2 h / 0 - 110 °C

5.2: pH ~ 9

6.1: sodium t-butanolate / dimethylsulfoxide-d6 / 2 h / 0 - 20 °C

6.2: 1 h / 20 °C

6.3: pH ~ 3

With pyridine; potassium tert-butylate; potassium carbonate; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dimethylsulfoxide-d6; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

2-(2-cyanophenoxy)acetamide (54802-12-9) → (2S,4R)-1-(tert-butoxycarbonyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxylic acid (1315326-78-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 3 h / 80 °C

2.1: pyridine / tetrahydrofuran / 0 - 20 °C

3.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C

3.2: pH ~ 2

4.1: trichlorophosphate / 1,4-dioxane / 2 h / 0 - 110 °C

4.2: pH ~ 9

5.1: sodium t-butanolate / dimethylsulfoxide-d6 / 2 h / 0 - 20 °C

5.2: 1 h / 20 °C

5.3: pH ~ 3

With pyridine; potassium tert-butylate; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dimethylsulfoxide-d6; water; tert-butyl alcohol;

upstream raw materials:

4-chloro-2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidine

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

3-aminobenzofuran-2-carboxamide

salicylonitrile

Downstream raw materials:

(2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-fluorophenylamino)-2-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxy-phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl-)-2-vinylcyclopropyl)-1-((S)-3,3-dimethyl-2-(4-methylthiazol-2-ylamino)butanoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

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