2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Base Information

Chemical Name:2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
CAS No.:5291-32-7
Molecular Formula:C10H17NO3
Molecular Weight:199.25
Hs Code.:2933990090
Mol file:5291-32-7.mol

Synonyms:2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one;PRIMA-1MET;APR-246;PRIMA-1MET

Suppliers and Price of 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PRIMA-1MET
10mg
$ 403.00

TRC
2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one
1mg
$ 45.00

Tocris
PRIMA-1MET ≥98%(HPLC)
10
$ 151.00

Sigma-Aldrich
PRIMA-1Met ≥98% (HPLC)
5mg
$ 90.30

Sigma-Aldrich
PRIMA-1Met ≥98% (HPLC)
25mg
$ 364.00

Medical Isotopes, Inc.
2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one
10 mg
$ 625.00

DC Chemicals
PRIMA-1MET(APR-246) >98%
250 mg
$ 800.00

DC Chemicals
PRIMA-1MET(APR-246) >98%
100 mg
$ 450.00

CSNpharm
APR-246
50mg
$ 427.00

CSNpharm
APR-246
5mg
$ 77.00

Total 24 raw suppliers

Chemical Property of 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Chemical Property:

Melting Point:115-116 °C
Boiling Point:313.8±17.0 °C(Predicted)
PKA:13.99±0.10(Predicted)
PSA：49.77000
Density:1.20±0.1 g/cm3(Predicted)
LogP:-0.40350
Storage Temp.:Store at +4°C
Solubility.:Soluble in DMSO (up to 20 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

PRIMA-1MET ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description PRIMA-1MET?(5291-32-7) reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1?It induces p53-dependent mitochondrial apoptosis?via?activation of caspase-2.2?PRIMA-1MET?showed significant antitumor activity in multiple myeloma?via?activation of p733?and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET?has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7?PRIMA-1MET?probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8
Uses 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one is a small molecule that has shown promising preclinical activity in various cancer types. 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one shows antitumor activity in multiple myeloma by induction of p73 and Noxa.

Technology Process of 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

There total 3 articles about 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.82%