1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-

Base Information

Chemical Name:1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-
CAS No.:1807642-39-2
Molecular Formula:C16H10FN3O2S
Molecular Weight:327.33
Hs Code.:
Mol file:1807642-39-2.mol

Synonyms:1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-

Suppliers and Price of 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carbonitrile
10mg
$ 1320.00

TRC
5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carbonitrile
1mg
$ 165.00

Total 19 raw suppliers

Chemical Property of 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-

Chemical Property:

Boiling Point:558.9±60.0 °C(Predicted)
PKA:-0.53±0.11(Predicted)
PSA：84.13000
Density:1.36±0.1 g/cm3(Predicted)
LogP:3.87868

Purity/Quality:

99%, ^*data from raw suppliers

5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carbonitrile is an impurity of Vonoprazan a novel potassium-?competitive acid blocker for the treatment of acid-?related diseases.

Technology Process of 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-

There total 5 articles about 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

: 16133-25-8
Pyridine-3-sulfonyl chloride

: 1240948-77-9
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

: 1807642-39-2
5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 10 - 30 ℃; for 3h;

Reference yield: 58.3%

: 1240948-77-9
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

: pyridine-3-sulfonyl

: 1807642-39-2
5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile

Guidance literature:: 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile; With tetraethylammonium bromide; sodium hydride; In tetrahydrofuran; water; at 0 ℃; for 1h;

pyridine-3-sulfonyl; In tetrahydrofuran; water; for 3h;
DOI:10.1016/j.tet.2022.132669

Reference yield:

: 312307-38-3
2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile

: 1807642-39-2
5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / 1,4-dioxane / 12 h / 80 °C / Green chemistry

2: N-ethyl-N,N-diisopropylamine; dmap

With dmap; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1002/cctc.201900154