1240948-77-9

Usage

Uses

Used in Pharmaceutical Industry:
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is used as an impurity in Vonoprazan (V767010), a novel potassium-competitive acid blocker. Vonoprazan is utilized for the treatment of acid-related diseases, and the presence of 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile as an impurity is significant for the development and manufacturing process of the drug.
Application Reason:
The use of 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile in the pharmaceutical industry is primarily due to its association with Vonoprazan, a drug that targets acid-related disorders. As an impurity, it plays a role in the synthesis and formulation of the drug, which may have implications for its efficacy and safety profile. Understanding the properties and effects of 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile can help in optimizing the drug's development and ensuring its therapeutic benefits for patients.

Upstream product

• 1240948-72-4 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 
• 312307-38-3 2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile 
• 1240948-81-5 S-{3-cyano-5-(2-fluorophenyl)-1H-pyrrol-2-yl}benzenecarbothioate 
• 1240948-83-7 2,2'-disulfanediylbis[5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile] 
• 1240949-27-2 4-(2-fluorophenyl)-2-(iminomethyl)-4-oxobutanenitrile 
• 445-27-2 2'-Fluoroacetophenone 
• 655-15-2 2-bromo-2'-fluoroacetophenone 

Downstream Products

• 2098974-13-9 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt 
• 881677-11-8 5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde 
• 881674-56-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 881681-00-1 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine 
• 1807642-39-2 5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile 
• 2098974-13-9 (x)C₄H₄O₄*C₁₇H₁₆FN₃O₂S 
• 1883595-37-6 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carboxylic acid 
• 1883595-39-8 C₁₇H₁₄FN₃O₃S 

Relevant academic research and scientific papers

Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate

A first synthetic research concerning four observed metabolites and their deuterium-labeled analogues of reflux esophagitis drug vonoprazan fumarate is reported. Among which the synthetic methods of three metabolites M ? I, M-III, M-IV-Sul, and four stable isotop labeled analogues M-I-d4, M-II-d4, M-III-d4, M-IV-Sul-d4 have not yet been reported before. The structures of these compounds were elucidated on the basis of MS and NMR spectroscopy.

Synthesis method of 5-(2-fluorophenyl)-1H-pyrrole-3-formaldehyde

The invention discloses a synthetic method of 5-(2-fluorophenyl)-1H-pyrrole-3-formaldehyde, and belongs to the field of organic synthesis. The preparation method comprises the following steps: (1) reacting 2-fluoro acetophenone with a bromination reagent

Preparation method 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde

The invention provides a preparation method of 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde, which comprises the following steps of A: 2 - chlorine -5 - (2 - fluorophenyl) - 1H - pyrrole -3 - carbonitrile in a solvent. In the base and palladium

An Efficient, Scalable and Eco-friendly Synthesis of 4,5-substituted Pyrrole-3-Carbonitriles by Intramolecular Annulation on Pd/C and HZSM-5

An efficient and eco-friendly protocol for the synthesis of diverse 4,5-substituted 1H-pyrrole-3-carbonitriles has been developed using commercially available HZSM-5 and Pd/C as recyclable heterogeneous catalysts with more excellent yields (up to 98 %) than traditional liquids acids, and successfully applied in the practical synthesis of vonoprazan. The conspicuous features of this protocol are higher product yield, easy work-up, eco-friendly and reusability of catalysts.

Preparation method of vonoprazan key intermediate

The invention provides a preparation method of a vonoprazan key intermediate, and a target product is prepared in one step by implementing a reductive cyclization reaction on 2-[2-(2-fluobenzene)-2-oxo-ethyl]malononitrile (II) through a reducing agent lik

Substituted pyrrole-4-alkylamine compounds and application thereof

The invention relates to substituted pyrrole-4-alkylamine compounds and application thereof. The invention particularly provides application of compounds shown in a formula I, or optical isomers thereof, or racemates thereof, or solvates thereof, or pharm

METHOD FOR PRODUCING PYRROLE COMPOUND

The present invention provides a production method of a 3-cyanopyrrole compound possibly useful as an intermediate for pharmaceutical products. A production method of compound (II) including subjecting compound (I) to a reduction reaction, in which the af

Novel pyrroles derivative as well as preparation method and pharmaceutical application thereof

The invention relates to a novel pyrroles derivative as well as a preparation method and pharmaceutical application thereof. Specifically, the invention relates to the novel pyrroles derivative shown as a general formula (I) as well as pharmaceutically ac

A fumaric acid fertile norah approves key intermediate and its preparation method (by machine translation)

The present invention provides a kind of fumaric acid fertile norah approves key intermediate and its preparation method. The invention fumaric acid fertile norah approves a key intermediate in the preparation method mainly comprises 3 step process, the p

PROCESS FOR PRODUCING PYRROLE COMPOUND

The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of produci