tert-Butyl (1-(4-bromothiazol-2-yl)piperidin-4-yl)carbamate

Base Information

• Chemical Name: tert-Butyl (1-(4-bromothiazol-2-yl)piperidin-4-yl)carbamate
• CAS No.: 1289050-83-4
• Molecular Formula: C₁₃H₂₀BrN₃O₂S
• Molecular Weight: 362.291
• Hs Code.: 2934100090
• Mol file: 1289050-83-4.mol

Synonyms:tert-Butyl (1-(4-bromothiazol-2-yl)piperidin-4-yl)carbamate

Chemical Property of tert-Butyl (1-(4-bromothiazol-2-yl)piperidin-4-yl)carbamate

Chemical Property:

• PSA: 86.19000
• LogP: 3.66850
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

tert-butyl(1-(4-bromothiazol-2-yl)piperidin-4-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl (1-(4-bromothiazol-2-yl)piperidin-4-yl)carbamate

There total 1 articles about tert-Butyl (1-(4-bromothiazol-2-yl)piperidin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,4-dibromo-1,3-thiazole (4175-77-3) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → tert-butyl 1-(4-bromothiazol-2-yl)piperidin-4-ylcarbamate (1289050-83-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 100 - 120 ℃; for 4h; Microwave irradiation;

DOI:10.1021/jm200497t

Reference yield:

tert-butyl 1-(4-bromothiazol-2-yl)piperidin-4-ylcarbamate (1289050-83-4) + 4-Bromophenylboronic acid (5467-74-3) + trifluoroacetic acid (76-05-1) → tert-butyl 1-(4-(4-bromophenyl)thiazol-2-yl)piperidin-4-ylcarbamate trifluoroacetate (1341225-63-5)

Guidance literature:

tert-butyl 1-(4-bromothiazol-2-yl)piperidin-4-ylcarbamate; 4-Bromophenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; at 100 ℃; for 0.5h; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;

DOI:10.1021/jm200497t

upstream raw materials:

2,4-dibromo-1,3-thiazole

(piperidin-4-yl)carbamic acid tert-butyl ester

Downstream raw materials:

tert-butyl 1-(4-(4-bromophenyl)thiazol-2-yl)piperidin-4-ylcarbamate trifluoroacetate

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