Technology Process of (4R,5R)-5-(4-Methoxy-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (S)-1-methyl-heptyl ester
There total 8 articles about (4R,5R)-5-(4-Methoxy-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (S)-1-methyl-heptyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; dicyclohexyl-carbodiimide;
In
dichloromethane;
for 6h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 96 percent / imidazole, 4-(dimethylamino)pyridine / diethyl ether / Ambient temperature
2: 1.) BuLi / 1.) hexane, THF, 0 deg C, 1 h, 2.) -78 deg C, 1 h
3: 96 percent / 1 M hydrochloric acid / acetone / 2 h
4: 82 percent / NaBH4 / ethanol / 0.67 h / Ambient temperature
5: 4-toluenesulfonic acid / Ambient temperature
6: 73 percent / yellow mercuric oxide, BF3*Et2O / tetrahydrofuran; H2O / 1 h / Ambient temperature
7: 87 percent / silver oxide / Ambient temperature
8: 70 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH2Cl2 / 6 h / Ambient temperature
With
1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; mercury(II) oxide; silver(l) oxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; acetone;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) BuLi / 1.) hexane, THF, 0 deg C, 1 h, 2.) -78 deg C, 1 h
2: 96 percent / 1 M hydrochloric acid / acetone / 2 h
3: 82 percent / NaBH4 / ethanol / 0.67 h / Ambient temperature
4: 4-toluenesulfonic acid / Ambient temperature
5: 73 percent / yellow mercuric oxide, BF3*Et2O / tetrahydrofuran; H2O / 1 h / Ambient temperature
6: 87 percent / silver oxide / Ambient temperature
7: 70 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH2Cl2 / 6 h / Ambient temperature
With
hydrogenchloride; dmap; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; mercury(II) oxide; silver(l) oxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone;
