(4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid

Base Information

• Chemical Name: (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid
• CAS No.: 130796-33-7
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.267

Synonyms:(4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid

Chemical Property of (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid

There total 21 articles about (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carbaldehyde (130718-76-2) → (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid (130796-33-7)

Guidance literature:

With silver(l) oxide; Ambient temperature;

Reference yield:

(S)-4-methoxymandelonitrile (33646-40-1,97070-73-0,133269-64-4,139406-83-0) → (4R,5S)-5-(4-Methoxy-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (127489-32-1,130796-33-7,130796-34-8)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Raney nickel

2: NaHSO₃

3: H(+)

4: KOH / aq. ethanol / 15 h / Heating

With potassium hydroxide; hydrogen; hydrogen cation; sodium hydrogensulfite; nickel; In ethanol;

DOI:10.1016/S0040-4039(01)93473-2

Reference yield:

5-(4-Methoxy-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonitrile (344256-01-5) → (4R,5S)-5-(4-Methoxy-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (127489-32-1,130796-33-7,130796-34-8)

Guidance literature:

With potassium hydroxide; In ethanol; for 15h; Heating;

DOI:10.1016/S0040-4039(01)93473-2

upstream raw materials:

(4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carbaldehyde

methyl (R)-2-hydroxy-2-(4-methoxyphenyl)acetate

methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

erythro (2R,3R)-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propane-2,3-diol

Downstream raw materials:

methyl (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

(4R,5R)-5-(4-Methoxy-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (S)-1-methyl-heptyl ester

(-)-(2R,3R)-methyl-2,3-dihydroxy-3-para-methoxyphenyl-propanoate

methyl cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

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