3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

Base Information

Chemical Name:3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline
CAS No.:64194-97-4
Molecular Formula:C₂₅H₂₂Cl₂N₄O₄
Molecular Weight:513.38
Hs Code.:

Synonyms:3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

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Chemical Property of 3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

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Technology Process of 3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

There total 6 articles about 3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.7%

: 64194-96-3
3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

: 75-36-5
acetyl chloride

: 64194-97-4
3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

Guidance literature:: In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00354a015

Reference yield:

: 3589-41-1
phenylmethyl cyanomethylcarbamate

: 64194-97-4
3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: HCl gas / diethyl ether / 0 °C

2: 2.) AcOH / 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h

3: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

4: 81.7 percent / dimethylformamide / Ambient temperature

With hydrogenchloride; hydrazine hydrate; acetic acid; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00354a015

Reference yield:

: 51030-44-5
ethyl 2-benzyloxycarbonylaminoacetimidate hydrochloride

: 64194-97-4
3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) AcOH / 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h

2: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

3: 81.7 percent / dimethylformamide / Ambient temperature

With hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00354a015