3-{3-bromo-5-chloro-4-[3-chloro-5-(3-hydroxy-propyl)-2-methoxymethoxy-phenoxy]-phenyl}-propan-1-ol

Base Information

Chemical Name:3-{3-bromo-5-chloro-4-[3-chloro-5-(3-hydroxy-propyl)-2-methoxymethoxy-phenoxy]-phenyl}-propan-1-ol
CAS No.:704913-00-8
Molecular Formula:C₂₀H₂₃BrCl₂O₅
Molecular Weight:494.21
Hs Code.:

Synonyms:3-{3-bromo-5-chloro-4-[3-chloro-5-(3-hydroxy-propyl)-2-methoxymethoxy-phenoxy]-phenyl}-propan-1-ol

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Chemical Property of 3-{3-bromo-5-chloro-4-[3-chloro-5-(3-hydroxy-propyl)-2-methoxymethoxy-phenoxy]-phenyl}-propan-1-ol

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Technology Process of 3-{3-bromo-5-chloro-4-[3-chloro-5-(3-hydroxy-propyl)-2-methoxymethoxy-phenoxy]-phenyl}-propan-1-ol

There total 6 articles about 3-{3-bromo-5-chloro-4-[3-chloro-5-(3-hydroxy-propyl)-2-methoxymethoxy-phenoxy]-phenyl}-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 704912-99-2
acetic acid 3-{4-[5-(3-acetoxy-propyl)-3-chloro-2-methoxymethoxy-phenoxy]-3-bromo-5-chloro-phenyl}-propyl ester

: 704913-00-8
3-{3-bromo-5-chloro-4-[3-chloro-5-(3-hydroxy-propyl)-2-methoxymethoxy-phenoxy]-phenyl}-propan-1-ol

Guidance literature:: With methanol; potassium carbonate; at 20 ℃;
DOI:10.1016/j.bmc.2005.11.055

Reference yield:

: 80373-18-8
3-(4'-hydroxyphenyl)-1-propyl acetate

: 704913-00-8
3-{3-bromo-5-chloro-4-[3-chloro-5-(3-hydroxy-propyl)-2-methoxymethoxy-phenoxy]-phenyl}-propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / SO₂Cl₂ / 5 h / 0 °C

2: 100 percent / pyridine*HBr₃; pyridine / CHCl₃ / 3 h / 0 °C

3: 50 percent / LiClO₄ / Electrochemical reaction

4: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

5: 100 percent / DIPEA / CH₂Cl₂

6: 100 percent / K₂CO₃; MeOH / 20 °C

With pyridine; methanol; sulfuryl dichloride; pyridinium perbromide hydrobromide; lithium perchlorate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/j.bmc.2005.11.055

Reference yield:

: 704912-87-8
3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate

: 704913-00-8
3-{3-bromo-5-chloro-4-[3-chloro-5-(3-hydroxy-propyl)-2-methoxymethoxy-phenoxy]-phenyl}-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / LiClO₄ / Electrochemical reaction

2: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

3: 100 percent / DIPEA / CH₂Cl₂

4: 100 percent / K₂CO₃; MeOH / 20 °C

With methanol; lithium perchlorate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2005.11.055