2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene

Base Information

• Chemical Name: 2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene
• CAS No.: 365448-98-2
• Molecular Formula: C₁₇H₂₄BrN
• Molecular Weight: 322.288
• Mol file: 365448-98-2.mol

Synonyms:2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene

Chemical Property of 2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene

There total 1 articles about 2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromo-1,5-di-t-butyl-3-(cyanomethyl)benzene (159556-96-4) + methyl iodide (74-88-4) → 2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene (365448-98-2)

Guidance literature:

2-bromo-1,5-di-t-butyl-3-(cyanomethyl)benzene; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at 0 ℃;

methyl iodide; In tetrahydrofuran; n-heptane; ethylbenzene; at 20 ℃; for 24h;

DOI:10.1002/hc.1063

Reference yield: 94.0%

2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene (365448-98-2) → 2-bromo-1,5-di-t-butyl-3-(1-formylethyl)benzene (365448-99-3)

Guidance literature:

2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene; With diisobutylaluminium hydride; In benzene; at 20 ℃; for 4h;

With sulfuric acid; In benzene;

DOI:10.1002/hc.1063

Reference yield:

2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene (365448-98-2) → 1,2-bis(2,4-di-t-butyl-6-isopropylphenyl)diphosphene

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisobutylaluminum hydride / benzene / 4 h / 20 °C

1.2: 94 percent / H₂SO₄ / benzene

2.1: 71 percent / hydrazine monohydrate; KOH / triethylene glycol; H₂O / 6 h / 200 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 88 percent / PCl₃ / tetrahydrofuran; hexane / 1.5 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 20 °C

4.2: tetrahydrofuran / 0.5 h / 20 °C

4.3: 4 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 0 °C

With potassium hydroxide; n-butyllithium; diisobutylaluminium hydride; hydrazine hydrate; In tetrahydrofuran; hexane; water; benzene; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; 2.1: Wolff-Kishner reduction;

DOI:10.1002/hc.1063

upstream raw materials:

2-bromo-1,5-di-t-butyl-3-(cyanomethyl)benzene

methyl iodide

Downstream raw materials:

2-bromo-1,5-di-t-butyl-3-(1-formylethyl)benzene

2-bromo-1,5-di-tert-butyl-3-isopropylbenzene

(2,4-di-t-butyl-6-isopropylphenyl)phosphine

(2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride