Toluene-4-sulfonic acid (2R,3R,5S)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (2R,3R,5S)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester
CAS No.:184297-12-9
Molecular Formula:C₂₃H₃₃N₅O₅SSi
Molecular Weight:519.697
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (2R,3R,5S)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

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Chemical Property of Toluene-4-sulfonic acid (2R,3R,5S)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

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Technology Process of Toluene-4-sulfonic acid (2R,3R,5S)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

There total 7 articles about Toluene-4-sulfonic acid (2R,3R,5S)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 184297-07-2
Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester

: 184297-12-9
Toluene-4-sulfonic acid (2R,3R,5S)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 115 ℃; for 2.5h;
DOI:10.1021/ja962117m

Reference yield:

: O^3'_,O5'-(1,1,3,3-tetraisopropyl-disiloxane-1,3-diyl)-O^2'-(toluene-4-sulfonyl)-adenosine

: 184297-12-9
Toluene-4-sulfonic acid (2R,3R,5S)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NH₄F / methanol / Ambient temperature

2: 66 percent / pyridine / Ambient temperature

3: 85 percent / DMAP / acetonitrile / 6 h / Ambient temperature

4: 88 percent / Bu₃SnH, AIBN / toluene / 2.5 h / 115 °C

With pyridine; dmap; ammonium fluoride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In methanol; toluene; acetonitrile;
DOI:10.1021/ja962117m

Reference yield:

: 69304-45-6
3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine

: 184297-12-9
Toluene-4-sulfonic acid (2R,3R,5S)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / Ambient temperature

2: NH₄F / methanol / Ambient temperature

3: 66 percent / pyridine / Ambient temperature

4: 85 percent / DMAP / acetonitrile / 6 h / Ambient temperature

5: 88 percent / Bu₃SnH, AIBN / toluene / 2.5 h / 115 °C

With pyridine; dmap; ammonium fluoride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In methanol; toluene; acetonitrile;
DOI:10.1021/ja962117m