Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester
CAS No.:184297-07-2
Molecular Formula:C₃₀H₃₇N₅O₇S₂Si
Molecular Weight:671.871
Hs Code.:

Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester

Synonyms:Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester

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Chemical Property of Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester

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Technology Process of Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester

There total 6 articles about Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 115094-43-4
5'-O-(tert-butyldimethylsilyl)-2'-O-(p-tolylsulfonyl)adenosine

: 1005-56-7
phenylcarbonochloridothioate

: 184297-07-2
Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester

Guidance literature:: With dmap; In acetonitrile; for 6h; Ambient temperature;
DOI:10.1021/ja962117m

Reference yield:

: 69304-45-6
3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine

: 184297-07-2
Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / Ambient temperature

2: NH₄F / methanol / Ambient temperature

3: 66 percent / pyridine / Ambient temperature

4: 85 percent / DMAP / acetonitrile / 6 h / Ambient temperature

With pyridine; dmap; ammonium fluoride; In methanol; acetonitrile;
DOI:10.1021/ja962117m

Reference yield:

: O^3'_,O5'-(1,1,3,3-tetraisopropyl-disiloxane-1,3-diyl)-O^2'-(toluene-4-sulfonyl)-adenosine

: 184297-07-2
Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NH₄F / methanol / Ambient temperature

2: 66 percent / pyridine / Ambient temperature

3: 85 percent / DMAP / acetonitrile / 6 h / Ambient temperature

With pyridine; dmap; ammonium fluoride; In methanol; acetonitrile;
DOI:10.1021/ja962117m