N-[2-(3-acetyl-1-benzyl-4H-pyridin-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide

Base Information

• Chemical Name: N-[2-(3-acetyl-1-benzyl-4H-pyridin-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide
• CAS No.: 1620644-83-8
• Molecular Formula: C₃₁H₃₂N₂O₄
• Molecular Weight: 496.606
• Mol file: 1620644-83-8.mol

Synonyms:N-[2-(3-acetyl-1-benzyl-4H-pyridin-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide

Chemical Property of N-[2-(3-acetyl-1-benzyl-4H-pyridin-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(3-acetyl-1-benzyl-4H-pyridin-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide

There total 4 articles about N-[2-(3-acetyl-1-benzyl-4H-pyridin-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-(benzylamino) but-3-en-2-one (53133-41-8) + 3,4-dimethoxy-N-[(E)-5-oxopent-3-enyl]-N-phenyl-benzamide (1620646-07-2) → N-[2-(3-acetyl-1-benzyl-4H-pyridin-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide (1620644-83-8)

Guidance literature:

With sodium sulfate; scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 48h;

Reference yield:

N-but-3-enyl-3,4-dimethoxy-N-phenyl-benzamide (1620646-06-1) → N-[2-(3-acetyl-1-benzyl-4H-pyridin-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide (1620644-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 40 °C / Inert atmosphere

2: scandium tris(trifluoromethanesulfonate); sodium sulfate / dichloromethane / 48 h / 20 °C

With Hoveyda-Grubbs catalyst second generation; sodium sulfate; scandium tris(trifluoromethanesulfonate); In dichloromethane;

Reference yield:

benzylamine (100-46-9) → N-[2-(3-acetyl-1-benzyl-4H-pyridin-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide (1620644-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform / 20 °C

2: scandium tris(trifluoromethanesulfonate); sodium sulfate / dichloromethane / 48 h / 20 °C

With sodium sulfate; scandium tris(trifluoromethanesulfonate); In dichloromethane; chloroform;

upstream raw materials:

benzylamine

4-(benzylamino) but-3-en-2-one

3,4-dimethoxy-N-[(E)-5-oxopent-3-enyl]-N-phenyl-benzamide

N-phenyl-3,4-dimethoxybenzamide

Downstream raw materials:

N-[2-(3-acetyl-1-benzyl-pyridin-1-ium-4-yl)ethyl]-3,4-dimethoxy-N-phenyl-benzamide 2,3-dichloro-5,6-dicyano-4-oxo-cyclohex-1,5-dien-1-olate