5-(benzyloxy)-1,2,3,6,7,8-hexahydro-8-methyl-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo<1,2-b:4,3-b'>dipyrrole-1-methanol acetate

Base Information

Chemical Name:5-(benzyloxy)-1,2,3,6,7,8-hexahydro-8-methyl-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo<1,2-b:4,3-b'>dipyrrole-1-methanol acetate
CAS No.:108833-11-0
Molecular Formula:C₂₃H₂₆N₂O₆S₂
Molecular Weight:490.601
Hs Code.:

Synonyms:5-(benzyloxy)-1,2,3,6,7,8-hexahydro-8-methyl-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo<1,2-b:4,3-b'>dipyrrole-1-methanol acetate

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Chemical Property of 5-(benzyloxy)-1,2,3,6,7,8-hexahydro-8-methyl-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo<1,2-b:4,3-b'>dipyrrole-1-methanol acetate

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Technology Process of 5-(benzyloxy)-1,2,3,6,7,8-hexahydro-8-methyl-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo<1,2-b:4,3-b'>dipyrrole-1-methanol acetate

There total 14 articles about 5-(benzyloxy)-1,2,3,6,7,8-hexahydro-8-methyl-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo<1,2-b:4,3-b'>dipyrrole-1-methanol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 112089-53-9
5-(benzyloxy)-1,2,3,6,7,8-hexahydro-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo[1,2-b:4,3-b']dipyrrole-1-methanol acetate

: 74-88-4
methyl iodide

: 108833-11-0
5-(benzyloxy)-1,2,3,6,7,8-hexahydro-8-methyl-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo<1,2-b:4,3-b'>dipyrrole-1-methanol acetate

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; acetone; for 4.5h;
DOI:10.1021/jm00398a017

Reference yield:

: 112089-54-0
6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-1H-indole-3-methanol acetate

: 108833-11-0
5-(benzyloxy)-1,2,3,6,7,8-hexahydro-8-methyl-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo<1,2-b:4,3-b'>dipyrrole-1-methanol acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / nitric acid / nitromethane / 0.67 h / 0 °C

2: 81 percent / hydrogen / 84.5percent PtO₂ / tetrahydrofuran; ethanol / 2 h / 2068.6 Torr

3: 1.) sulfuryl chloride, 2.) 1,8-bis(dimethylamino)naphthalene / 1.) methylene chloride, -78 deg C, 20 min, 2.) -78 deg C, 4.1 h

4: 84 percent / Na₂CO₃ / acetone; dimethylformamide / 4.5 h

With sulfuryl dichloride; hydrogen; nitric acid; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium carbonate; platinum(IV) oxide; In tetrahydrofuran; nitromethane; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00398a017

Reference yield:

: 106014-85-1
6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline

: 108833-11-0
5-(benzyloxy)-1,2,3,6,7,8-hexahydro-8-methyl-3-(methylsulfonyl)-8-(methylthio)-7-oxobenzo<1,2-b:4,3-b'>dipyrrole-1-methanol acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium acetate, 2.) triethylamine / 1.) ethanol, reflux, 20 h, 2.) methylene chloride

2: 64 percent / nitric acid / nitromethane / 0.67 h / 0 °C

3: 81 percent / hydrogen / 84.5percent PtO₂ / tetrahydrofuran; ethanol / 2 h / 2068.6 Torr

4: 1.) sulfuryl chloride, 2.) 1,8-bis(dimethylamino)naphthalene / 1.) methylene chloride, -78 deg C, 20 min, 2.) -78 deg C, 4.1 h

5: 84 percent / Na₂CO₃ / acetone; dimethylformamide / 4.5 h

With sulfuryl dichloride; hydrogen; nitric acid; sodium acetate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium carbonate; triethylamine; platinum(IV) oxide; In tetrahydrofuran; nitromethane; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00398a017