106014-85-1Relevant articles and documents
AN ALTERNATIVE METHOD FOR SYNTHESIS OF THE CC-1065 PHARMACOPHORE, 1,2,7,7a-TETRAHYDROCYCLOPROPINDOL-4-ONE
Wang, Yugiang,Lown, J. William
, p. 1399 - 1410 (2007/10/02)
The synthesis of the CC-1065 pharmacophore, 2-(1-methylpyrrole-2-carbonyl)-1,2,7,7a-tetrahydrocyclopropindol-4-one (17), is described.The methods reported here provide an alternative route for the synthesis of compounds possessing the biologically
Total Synthesis of U-71,184, A Potent New Antitumor Agent Modeled on CC-1065
Warpehoski, M.A.
, p. 4103 - 4106 (2007/10/02)
The synthesis of U-71,184 (2), a highly potent analog of the novel antitumor antibiotic CC-1065, is described, the penultimate step of which involves the unmasking of a p-hydroxy phenethyl mesylate, which undergoes facile intramolecular elimination to aff
