ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)propanoate

Base Information

Chemical Name:ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)propanoate
CAS No.:1416732-26-7
Molecular Formula:C₂₀H₁₉F₄N₅O₃
Molecular Weight:453.396
Hs Code.:

Synonyms:ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)propanoate

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Chemical Property of ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)propanoate

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Technology Process of ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)propanoate

There total 6 articles about ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1416732-24-5
(E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate

: 1416732-26-7
ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)propanoate

Guidance literature:: With hydrogen; palladium-on-charcoal; In ethanol; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1416732-26-7
ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

3.1: diethyl ether / 0 - 20 °C

4.1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / acetonitrile / 20 - 90 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

6.1: hydrogen / palladium-on-charcoal / ethanol / 3 h / 20 °C / Inert atmosphere

With n-butyllithium; hydrogen; copper; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium-on-charcoal; palladium diacetate; In diethyl ether; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1416732-26-7
ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

2: diethyl ether / 0 - 20 °C

3: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / acetonitrile / 20 - 90 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

5: hydrogen / palladium-on-charcoal / ethanol / 3 h / 20 °C / Inert atmosphere

With n-butyllithium; hydrogen; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium-on-charcoal; palladium diacetate; In diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; acetonitrile;