(E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate
CAS No.:1416732-24-5
Molecular Formula:C₂₀H₁₇F₄N₅O₃
Molecular Weight:451.38
Hs Code.:

Synonyms:(E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate

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Chemical Property of (E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate

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Technology Process of (E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate

There total 5 articles about (E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.6%

: 288-94-8
1H-tetrazole

: C₁₉H₁₅F₄NO₃

: 1416732-24-5
(E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 65 ℃; Inert atmosphere;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1416732-24-5
(E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

3.1: diethyl ether / 0 - 20 °C

4.1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / acetonitrile / 20 - 90 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

With n-butyllithium; copper; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1416732-24-5
(E)-ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

2: diethyl ether / 0 - 20 °C

3: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / acetonitrile / 20 - 90 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In diethyl ether; hexane; N,N-dimethyl-formamide; acetonitrile;