tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Base Information

Chemical Name:tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate
CAS No.:1092938-16-3
Molecular Formula:C₂₈H₃₄N₂O₄
Molecular Weight:462.589
Hs Code.:

Synonyms:tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

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Chemical Property of tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

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Technology Process of tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

There total 10 articles about tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 850036-28-1
cyclopenten-1-ylboronic acid

: 1092938-82-3
tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

: 1092938-16-3
tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; for 12h; Inert atmosphere; Reflux;

Reference yield:

: 62327-21-3
tert-butyl dimethylphosphonoacetate

: 1092938-16-3
tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Cooling

1.2: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

3.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 12 h / Inert atmosphere; Reflux

With hydrogen; sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1092938-16-3
tert-butyl (6R)-6-[(5-cyclopent-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Guidance literature:: Multi-step reaction with 6 steps

1: diethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: 1.5 h / 210 °C

3: N-Bromosuccinimide / tetrachloromethane / 60 °C

4: hydrogenchloride; isopentyl nitrite / 1,4-dioxane; chloroform / 3 h / Reflux

5: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

6: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 12 h / Inert atmosphere; Reflux

With hydrogenchloride; N-Bromosuccinimide; sodium hydride; sodium carbonate; diethylamine; isopentyl nitrite; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; chloroform; water; N,N-dimethyl-formamide;