(R)-alpha-(Trifluoromethyl)-4-fluorobenzenemethanol

Base Information

Chemical Name:(R)-alpha-(Trifluoromethyl)-4-fluorobenzenemethanol
CAS No.:848926-12-5
Molecular Formula:C₈H₆F₄O
Molecular Weight:194.129
Hs Code.:
European Community (EC) Number:959-247-6
Nikkaji Number:J371.093I

Synonyms:848926-12-5;(1R)-2,2,2-trifluoro-1-(4-fluorophenyl)ethan-1-ol;(R)-2,2,2-Trifluoro-1-(4-fluorophenyl)ethan-1-ol;(R)-alpha-(Trifluoromethyl)-4-fluorobenzenemethanol;SCHEMBL1273068;2,2,2-trifluoro-1(R)-(4-fluorophenyl)ethanol;EN300-1929548;(1R)-2,2,2-trifluoro-1-(4-fluorophenyl)ethanol;2,2,2-trifluoro-1 (R)-(4-fluorophenyl)ethanol

Suppliers and Price of (R)-alpha-(Trifluoromethyl)-4-fluorobenzenemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-alpha-(Trifluoromethyl)-4-fluorobenzenemethanol

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:194.03547746
Heavy Atom Count:13
Complexity:160

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(C(F)(F)F)O)F
Isomeric SMILES:C1=CC(=CC=C1[C@H](C(F)(F)F)O)F

Technology Process of (R)-alpha-(Trifluoromethyl)-4-fluorobenzenemethanol

There total 5 articles about (R)-alpha-(Trifluoromethyl)-4-fluorobenzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 655-32-3
2,2,2-trifluoro-1-(4-fluorophenyl)ethanone

: 848926-12-5
(R)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethanol

: 890085-08-2
(S)-4-fluoro-α,α,α-(trifluoromethyl)-benzenemethanol

Guidance literature:: 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone; With (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In dichloromethane; at -78 - -75 ℃; Cooling with ice; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at -75 - 20 ℃; Cooling with ice; Inert atmosphere;

Reference yield: 87.0%

: 655-32-3
2,2,2-trifluoro-1-(4-fluorophenyl)ethanone

: 848926-12-5
(R)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethanol

Guidance literature:: With benzo[1,3,2]dioxaborole; S-CBS catalyst; In dichloromethane; toluene; at -78 ℃; for 16h;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 848926-12-5
(R)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethanol

: 890085-08-2
(S)-4-fluoro-α,α,α-(trifluoromethyl)-benzenemethanol

Guidance literature:: 4-fluorobenzaldehyde; With N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide; [1,3-bis(2,6-di-iso-propylphenyl)imidazol-2-ylidene]copper(I) fluoride; In toluene; at -78 ℃; for 0.166667h; Inert atmosphere;

(trifluoromethyl)trimethylsilane; In toluene; at -78 ℃; for 2h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Overall yield = 79 %; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.jfluchem.2013.01.027