carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester

Base Information

Chemical Name:carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester
CAS No.:1207274-75-6
Molecular Formula:C₂₁H₂₁F₂NO₃
Molecular Weight:373.399
Hs Code.:

Synonyms:carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester

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Technology Process of carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester

There total 1 articles about carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 552831-23-9
(R)-imidazole-1-carboxylic acid 1-azabicyclo[2.2.2]oct-3-yl ester

: 98586-21-1
bis(3-fluorophenyl)methanol

: 1207274-75-6
carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester

Guidance literature:: bis(3-fluorophenyl)methanol; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

(R)-imidazole-1-carboxylic acid 1-azabicyclo[2.2.2]oct-3-yl ester; In tetrahydrofuran; hexane; at 0 ℃; for 1.5h;

Reference yield: 62.0%

: 1207274-75-6
carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester

: 5349-17-7
4-bromoacetylpyridine hydrobromide

: 1207275-37-3
(R)-3-[bis-(3-fluoro-phenyl)-methoxycarbonyloxy]-1-(2-oxo-2-pyridin-4-yl-ethyl)-1-azonia-bicyclo[2.2.2]octane bromide

Guidance literature:: 4-bromoacetylpyridine hydrobromide; With N-ethyl-N,N-diisopropylamine; In ethyl acetate; for 0.166667h;

carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester; In ethyl acetate; at 20 ℃; for 2h;