(2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol

Base Information

Chemical Name:(2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol
CAS No.:1044589-94-7
Molecular Formula:C₂₇H₂₀Cl₅N₃O₄
Molecular Weight:627.738
Hs Code.:

Synonyms:(2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol

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Chemical Property of (2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol

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Technology Process of (2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol

There total 5 articles about (2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.8%

: ((3R,4R,5R)-2-bromo-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol)

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1044589-94-7
(2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol

Guidance literature:: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine; With sodium hydride; In acetonitrile; mineral oil; at 25 ℃; for 0.5h;

((3R,4R,5R)-2-bromo-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol); In acetonitrile; mineral oil; at 25 ℃; for 12h;

Reference yield:

: (3R,4R,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-2,3-diol

: 1044589-94-7
(2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; hydrogen bromide / dichloromethane / 1.75 h / 20 °C

2.1: sodium hydride / acetonitrile; mineral oil / 0.5 h / 25 °C

2.2: 12 h / 25 °C

With hydrogen bromide; sodium hydride; acetic acid; In dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 636581-82-3
3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose

: 1044589-94-7
(2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 3 h / 0 °C

1.2: Cooling

2.1: hydrogen bromide; acetic acid / dichloromethane / 1.5 h / 20 °C

3.1: sodium hydride / acetonitrile / 0.5 h / 20 °C

3.2: 18 h / 20 °C

With hydrogen bromide; sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;