5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine
• CAS No.: 312709-92-5
• Molecular Formula: C₄₁H₅₃N₅O₈Si
• Molecular Weight: 771.986
• Mol file: 312709-92-5.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5'-O-(4,4'-dimethoxytrityl)-N2-acetyl-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine (253586-23-1) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine (312709-92-5)

Guidance literature:

With methylamine; In ethanol; at 20 ℃; for 1h;

DOI:10.1002/1522-2675(20000906)83:9<2477::AID-HLCA2477>3.0.CO;2-9

Reference yield: 81.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine (312709-92-5) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Guidance literature:

With N,N-diethyl-N-isopropylamine; In dichloromethane; at 20 ℃; for 14h;

DOI:10.1002/1522-2675(20000906)83:9<2477::AID-HLCA2477>3.0.CO;2-9

Reference yield: 74.0%

Phenoxyacetyl chloride (701-99-5) + 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine (312709-92-5) → N2,3'-O-bis(phenoxyacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropyl)silyloxy]methyl]guanosine (767338-06-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1002/anie.200460068

upstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-N²-acetyl-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine

Downstream raw materials:

N²,3'-O-bis(phenoxyacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropyl)silyloxy]methyl]guanosine

O⁶-(2,2,2-trichloroethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropyl)silyloxy]methyl]-N²-phenoxyacetylguanosine

N²,3'-O-bis(phenoxyacetyl)-O⁶-(2,2,2-trichloroethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropyl)silyloxy]methyl]guanosine

Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester