Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester
• CAS No.: 767338-07-8
• Molecular Formula: C₆₆H₇₅N₅O₁₄SSi
• Molecular Weight: 1222.5
• Mol file: 767338-07-8.mol

Synonyms:Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester

Chemical Property of Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester

There total 3 articles about Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-mesitylenesulphonyl chloride (773-64-8) + N2,3'-O-bis(phenoxyacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropyl)silyloxy]methyl]guanosine (767338-06-7) → Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester (767338-07-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/anie.200460068

Reference yield:

Phenoxyacetyl chloride (701-99-5) → Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester (767338-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Pyridine / CH₂Cl₂ / 2 h / 0 °C

2: DMAP; Et₃N / CH₂Cl₂ / 1 h / 20 °C

With pyridine; dmap; triethylamine; In dichloromethane;

DOI:10.1002/anie.200460068

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine (312709-92-5) → Phenoxy-acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-yl ester (767338-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Pyridine / CH₂Cl₂ / 2 h / 0 °C

2: DMAP; Et₃N / CH₂Cl₂ / 1 h / 20 °C

With pyridine; dmap; triethylamine; In dichloromethane;

DOI:10.1002/anie.200460068

upstream raw materials:

2-mesitylenesulphonyl chloride

N²,3'-O-bis(phenoxyacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropyl)silyloxy]methyl]guanosine

Phenoxyacetyl chloride

5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}guanosine

Downstream raw materials:

N²,3'-O-bis(phenoxyacetyl)-O⁶-(2,2,2-trichloroethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropyl)silyloxy]methyl]guanosine

O⁶-(2,2,2-trichloroethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropyl)silyloxy]methyl]-N²-phenoxyacetylguanosine