3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline

Base Information

Chemical Name:3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline
CAS No.:1195768-31-0
Molecular Formula:C₁₇H₁₆ClFN₄S
Molecular Weight:362.858
Hs Code.:

Synonyms:3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline

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Chemical Property of 3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline

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Technology Process of 3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline

There total 12 articles about 3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1195768-30-9
allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate

: 1195768-31-0
3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline

Guidance literature:: With tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; at 20 ℃; for 3h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 1353575-89-9
2-tert-butyl-5-(2-chloropyrimidin-4-yl)-4-(2-fluoro-3-nitrophenyl)thiazole

: 1195768-31-0
3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline

Guidance literature:: With iron; acetic acid; at 20 ℃; for 24h;

Reference yield:

: 1195768-18-3
3-amino-2-fluorobenzoic acid methyl ester

: 1195768-31-0
3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 - 0 °C / Inert atmosphere

2.2: 1.33 h / 0 - 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1 h / 20 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C / Inert atmosphere

4.1: tri-n-butyl-tin hydride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; water / 3 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; tri-n-butyl-tin hydride; sodium hydrogencarbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; water;