1195768-18-3

Basic information

• Product Name: methyl 3-amino-2-fluorobenzoate
• Synonyms: methyl 3-amino-2-fluorobenzoate;2-Fluoro-3-(methoxycarbonyl)aniline;3-amino-2-fluoroBenzoic acid Methyl ester;Methyl 2-fluoro-3-aminobenzoate;CL029
• CAS NO: 1195768-18-3
• Molecular Formula: C₈H₈FNO₂
• Molecular Weight: 169
• EINECS: 1533716-785-6
• Mol File: 1195768-18-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 295.978 °C at 760 mmHg
• Flash Point: 132.803 °C
• Appearance: /
• Density: 1.219 g/cm³
• Refractive Index: 1.5570 to 1.5610
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 2.06±0.10(Predicted)
• CAS DataBase Reference: methyl 3-amino-2-fluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-amino-2-fluorobenzoate(1195768-18-3)
• EPA Substance Registry System: methyl 3-amino-2-fluorobenzoate(1195768-18-3)

Safety Data

• Hazardous Substances Data: 1195768-18-3(Hazardous Substances Data)

Usage

Physical Form

Liquid

Uses

Methyl 3-amino-2-fluorobenzoate is a useful chemical compound.

Upstream product

• 873697-68-8 3-amino-2-fluorobenzonitrile 
• 437-86-5 2-fluoro-3-nitrotoluene 
• 206551-41-9 2-fluoro-3-bromobenzoic acid methyl ester 
• 161957-56-8 3-bromo-2-fluorobenzoic acid 
• 317-46-4 2-fluoro-3-nitro-benzoic acid 
• 1042055-86-6 methyl 3-((tert-butoxycarbonyl)amino)-2-fluorobenzoate 
• 946126-94-9 2-fluoro-3-nitrobenzoic acid methyl ester 
• 55775-97-8 2,6-dichloro-3-nitrobenzoic acid 
• 50-30-6 2,6-dichlorobenzoic acid 

Downstream Products

• 1195768-24-1 3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester 
• 1195768-26-3 methyl-3-[(allyloxy)carbonyl]amino-2-fluorobenzoate 
• 1195768-19-4 3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester 
• 1315305-53-3 methyl 2-fluoro-3-(2-fluoro-3-nitrobenzamido)benzoate 
• 918523-76-9 2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid methyl ester 
• 1307272-33-8 methyl 2-fluoro-3-{[(3,3,3-trifluoropropyl)sulfonyl]amino}benzoate 
• 1195768-27-4 (3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)allylcarbamate 
• 1195768-28-5 2-propen-1-yl {3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate 
• 1195768-29-6 3-(5-(2-chloropyrimidin-4-yl)-2-isopropylthiazol-4-yl)-2-fluoroaniline 
• 1195768-30-9 allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate 
• 1195768-31-0 3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline 
• 1195768-33-2 2-propen-1-yl {3-[5-(2-chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate 
• 1195768-34-3 3-(5-(2-chloropyrimidin-4-yl)-2-morpholinothiazol-4-yl)-2-fluoroaniline 
• 1195768-37-6 2-propen-1-yl {3-[5-(2-chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate 

Relevant articles and documents

From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)

The mitogen-activated protein kinase (MAP) kinase 4 (MKK4) was found to be a major regulator of liver regeneration and could be a valuable drug target addressing liver related diseases by restoring its intrinsic regenerative capacity. We report on the synthesis and optimization of novel MKK4 inhibitors following a target-hopping strategy from the FDA-approved BRAFV600E inhibitor PLX4032 (8). Applying an iterative multi-parameter optimization process we carved out essential structural features yielding in compounds with a low nanomolar affinity for MKK4 and excellent selectivity profiles against the main off-targets MKK7 and JNK1, which, upon relevant inhibition, would totally abrogate the pro-regenerative effect of MKK4 inhibition, as well as against the off-targets MAP4K5, ZAK and BRAF with selectivity factors ranging from 40 to 430 for our best-balanced compounds 70 and 73.

Synthesis method of anti-cancer drug intermediate methyl 2-fluoro-3-aminobenzoate

The invention discloses a synthetic method of 2-fluoro-3-methyl aminobenzoate, and belongs to the technical field of synthesis of medical intermediates. According to the method, 2, 6-dichlorobenzoic acid is taken as a raw material, 2, 6-dichloro-3-nitrobe

Thiazole kinase inhibitors

The invention belongs to the technical field of medicine, and particularly relates to a thiazole kinase inhibitor shown as a general formula (I), and pharmaceutically acceptable salts or stereisomers thereof, wherein R1, R2, R3, R4, m, n and p are defined