allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate

Base Information

Chemical Name:allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate
CAS No.:1195768-30-9
Molecular Formula:C₂₁H₂₀ClFN₄O₂S
Molecular Weight:446.933
Hs Code.:

Synonyms:allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate

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Chemical Property of allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate

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Technology Process of allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate

There total 9 articles about allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.4%

: 630-22-8
2,2-dimethylpropanethioamide

: 1195768-27-4
(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)allylcarbamate

: 1195768-30-9
allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate

Guidance literature:: (3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)allylcarbamate; With N-Bromosuccinimide; In ISOPROPYLAMIDE; at 20 ℃; for 1h; Inert atmosphere;

2,2-dimethylpropanethioamide; In ISOPROPYLAMIDE; at 0 - 20 ℃; for 2h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 206551-41-9
2-fluoro-3-bromobenzoic acid methyl ester

: 1195768-30-9
allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tert-butyl carbazate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 90 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 - 0 °C / Inert atmosphere

3.2: 1.33 h / 0 - 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1 h / 20 °C / Inert atmosphere

4.2: 2 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; tert-butyl carbazate; sodium hydrogencarbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; ISOPROPYLAMIDE; toluene;

Reference yield:

3-bromo-2-fluorobenzoic acid: 161957-56-8
3-bromo-2-fluorobenzoic acid

: 1195768-30-9
allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 1 h / Inert atmosphere; Reflux

2.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tert-butyl carbazate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 90 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 - 0 °C / Inert atmosphere

4.2: 1.33 h / 0 - 20 °C / Inert atmosphere

5.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1 h / 20 °C / Inert atmosphere

5.2: 2 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; tert-butyl carbazate; sulfuric acid; sodium hydrogencarbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; ISOPROPYLAMIDE; toluene;