methyl 3-(butylamino)-2,5-dihydro-2-oxo-1-phenyl-1H-pyrrole-4-carboxylate

Base Information

• Chemical Name: methyl 3-(butylamino)-2,5-dihydro-2-oxo-1-phenyl-1H-pyrrole-4-carboxylate
• CAS No.: 1374118-95-2
• Molecular Formula: C₁₆H₂₀N₂O₃
• Molecular Weight: 288.346
• Mol file: 1374118-95-2.mol

Synonyms:methyl 3-(butylamino)-2,5-dihydro-2-oxo-1-phenyl-1H-pyrrole-4-carboxylate

Chemical Property of methyl 3-(butylamino)-2,5-dihydro-2-oxo-1-phenyl-1H-pyrrole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 3-(butylamino)-2,5-dihydro-2-oxo-1-phenyl-1H-pyrrole-4-carboxylate

There total 3 articles about methyl 3-(butylamino)-2,5-dihydro-2-oxo-1-phenyl-1H-pyrrole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-butylamine (109-73-9,85404-21-3) + aniline (62-53-3) + dimethyl acetylenedicarboxylate (762-42-5) → methyl 3-(butylamino)-2,5-dihydro-2-oxo-1-phenyl-1H-pyrrole-4-carboxylate (1374118-95-2)

Guidance literature:

With saccharin; In methanol; at 20 ℃; for 4h; Green chemistry;

DOI:10.1007/s13738-016-0871-5

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C10H17NO4 + aniline (62-53-3) → methyl 3-(butylamino)-2,5-dihydro-2-oxo-1-phenyl-1H-pyrrole-4-carboxylate (1374118-95-2)

Guidance literature:

With oxalic acid; In methanol; at 20 ℃; for 3h;

DOI:10.3184/174751912X13547952669204

Reference yield:

dimethyl acetylenedicarboxylate (762-42-5) → methyl 3-(butylamino)-2,5-dihydro-2-oxo-1-phenyl-1H-pyrrole-4-carboxylate (1374118-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.5 h

2: oxalic acid / methanol / 3 h / 20 °C

With oxalic acid; In methanol;

DOI:10.3184/174751912X13547952669204

upstream raw materials:

formaldehyd

N-butylamine

aniline

dimethyl acetylenedicarboxylate