(1-{1-[1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(1-{1-[1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid tert-butyl ester
CAS No.:1054715-35-3
Molecular Formula:C₅₀H₆₂N₄O₆Si
Molecular Weight:843.151
Hs Code.:

(1-{1-[1-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(1-{1-[1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid tert-butyl ester

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Chemical Property of (1-{1-[1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid tert-butyl ester

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1-{1-[1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid tert-butyl ester

There total 9 articles about (1-{1-[1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132388-60-4,200625-96-3
(S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid

: 1054715-35-3
(1-{1-[1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 4-methylmorpholine / tetrahydrofuran / 20 h / -10 °C

2.1: NaBH₄ / H₂O / 5 h / 23 °C

3.1: 7.6 g / imidazole / dimethylformamide

4.1: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

5.1: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

6.1: i-Pr₂NEt / CH₂Cl₂

7.1: NaH / tetrahydrofuran / 0 °C

7.2: NaH / tetrahydrofuran / 61 h / Heating

With 4-methyl-morpholine; 1H-imidazole; sodium tetrahydroborate; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm010469k

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1054715-35-3
(1-{1-[1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 7.6 g / imidazole / dimethylformamide

2.1: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

3.1: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

4.1: i-Pr₂NEt / CH₂Cl₂

5.1: NaH / tetrahydrofuran / 0 °C

5.2: NaH / tetrahydrofuran / 61 h / Heating

With 1H-imidazole; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010469k

Reference yield:

: 199006-31-0
(1S)-[1-hydroxymethyl-3-(tritylcarbamoyl)propyl]carbamic acid benzyl ester

: 1054715-35-3
(1-{1-[1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethyl}-4-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 7.6 g / imidazole / dimethylformamide

2.1: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

3.1: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

4.1: i-Pr₂NEt / CH₂Cl₂

5.1: NaH / tetrahydrofuran / 0 °C

5.2: NaH / tetrahydrofuran / 61 h / Heating

With 1H-imidazole; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010469k