(1'S,2R)-methanesulfonic acid 1-[1'-(tert-butyldimethylsilanyloxymethyl)-3'-(tritylcarbamoyl)propylcarbamoyl]-2-phenylethyl ester

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Chemical Name:(1'S,2R)-methanesulfonic acid 1-[1'-(tert-butyldimethylsilanyloxymethyl)-3'-(tritylcarbamoyl)propylcarbamoyl]-2-phenylethyl ester
CAS No.:422322-92-7
Molecular Formula:C₄₀H₅₀N₂O₆SSi
Molecular Weight:714.998
Hs Code.:

Synonyms:(1'S,2R)-methanesulfonic acid 1-[1'-(tert-butyldimethylsilanyloxymethyl)-3'-(tritylcarbamoyl)propylcarbamoyl]-2-phenylethyl ester

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Chemical Property of (1'S,2R)-methanesulfonic acid 1-[1'-(tert-butyldimethylsilanyloxymethyl)-3'-(tritylcarbamoyl)propylcarbamoyl]-2-phenylethyl ester

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Technology Process of (1'S,2R)-methanesulfonic acid 1-[1'-(tert-butyldimethylsilanyloxymethyl)-3'-(tritylcarbamoyl)propylcarbamoyl]-2-phenylethyl ester

There total 8 articles about (1'S,2R)-methanesulfonic acid 1-[1'-(tert-butyldimethylsilanyloxymethyl)-3'-(tritylcarbamoyl)propylcarbamoyl]-2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132388-60-4,200625-96-3
(S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid

: 422322-92-7
(1'S,2R)-methanesulfonic acid 1-[1'-(tert-butyldimethylsilanyloxymethyl)-3'-(tritylcarbamoyl)propylcarbamoyl]-2-phenylethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 4-methylmorpholine / tetrahydrofuran / 20 h / -10 °C

2: NaBH₄ / H₂O / 5 h / 23 °C

3: 7.6 g / imidazole / dimethylformamide

4: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

5: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

6: i-Pr₂NEt / CH₂Cl₂

With 4-methyl-morpholine; 1H-imidazole; sodium tetrahydroborate; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm010469k

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 422322-92-7
(1'S,2R)-methanesulfonic acid 1-[1'-(tert-butyldimethylsilanyloxymethyl)-3'-(tritylcarbamoyl)propylcarbamoyl]-2-phenylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 7.6 g / imidazole / dimethylformamide

2: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

3: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

4: i-Pr₂NEt / CH₂Cl₂

With 1H-imidazole; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010469k

Reference yield:

: 199006-31-0
(1S)-[1-hydroxymethyl-3-(tritylcarbamoyl)propyl]carbamic acid benzyl ester

: 422322-92-7
(1'S,2R)-methanesulfonic acid 1-[1'-(tert-butyldimethylsilanyloxymethyl)-3'-(tritylcarbamoyl)propylcarbamoyl]-2-phenylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 7.6 g / imidazole / dimethylformamide

2: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

3: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

4: i-Pr₂NEt / CH₂Cl₂

With 1H-imidazole; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010469k