dibenzyl 2-{4-[(2S)-2-({(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

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Chemical Name:dibenzyl 2-{4-[(2S)-2-({(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonate
CAS No.:221077-09-4
Molecular Formula:C₄₇H₅₅N₃O₁₁
Molecular Weight:837.967
Hs Code.:

Synonyms:dibenzyl 2-{4-[(2S)-2-({(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

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Chemical Property of dibenzyl 2-{4-[(2S)-2-({(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

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Technology Process of dibenzyl 2-{4-[(2S)-2-({(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

There total 3 articles about dibenzyl 2-{4-[(2S)-2-({(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 13798-75-9
N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

: dibenzyl 2-{4-[(2S)-2-amino-3-oxo-3-(pentylamino)propyl]phenoxy}malonate hydrochloride

: 221077-09-4
dibenzyl 2-{4-[(2S)-2-({(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

Guidance literature:: With triethylamine; at 0 ℃; for 16h;
DOI:10.1021/jm010393s

Reference yield:

: 65100-24-5
dibenzyl 2-bromomalonate

: 221077-09-4
dibenzyl 2-{4-[(2S)-2-({(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / K₂CO₃ / acetone / 20 °C

2: 98 percent / AcOH; HCl / 2 h / 20 °C

3: 87 percent / Et₃N / 16 h / 0 °C

With hydrogenchloride; potassium carbonate; acetic acid; triethylamine; In acetone;
DOI:10.1021/jm010393s

Reference yield:

: 221077-07-2
dibenzyl 2-{4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

: 221077-09-4
dibenzyl 2-{4-[(2S)-2-({(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / AcOH; HCl / 2 h / 20 °C

2: 87 percent / Et₃N / 16 h / 0 °C

With hydrogenchloride; acetic acid; triethylamine;
DOI:10.1021/jm010393s