4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid

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Chemical Name:4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid
CAS No.:221077-11-8
Molecular Formula:C₄₆H₅₁N₃O₁₂
Molecular Weight:837.924
Hs Code.:

4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid

Synonyms:4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid

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Chemical Property of 4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid

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Technology Process of 4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid

There total 4 articles about 4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 108-30-5
succinic acid anhydride

: 2-{4-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-2-pentylcarbamoyl-ethyl]-phenoxy}-malonic acid dibenzyl ester; hydrochloride

: 221077-11-8
4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 16h;
DOI:10.1021/jm010393s

Reference yield:

: 65100-24-5
dibenzyl 2-bromomalonate

: 221077-11-8
4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 35 percent / K₂CO₃ / acetone / 20 °C

2: 98 percent / AcOH; HCl / 2 h / 20 °C

3: 87 percent / Et₃N / 16 h / 0 °C

4: 100 percent / AcOH; HCl / 2 h

5: 70 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

With hydrogenchloride; potassium carbonate; acetic acid; triethylamine; In dichloromethane; acetone;
DOI:10.1021/jm010393s

Reference yield:

: 221077-07-2
dibenzyl 2-{4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

: 221077-11-8
4-{[(1S)-3-(benzyloxy)-1-({[(1S)-1-(4-{2-(benzyloxy)-1-[(benzyloxy)carbonyl]-2-oxoethoxy}benzyl)-2-oxo-2-(pentylamino)ethyl]amino}carbonyl)-2-oxopropyl]amino}-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / AcOH; HCl / 2 h / 20 °C

2: 87 percent / Et₃N / 16 h / 0 °C

3: 100 percent / AcOH; HCl / 2 h

4: 70 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

With hydrogenchloride; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/jm010393s