(4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester

Base Information

• Chemical Name: (4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester
• CAS No.: 318464-25-4
• Molecular Formula: C₂₂H₃₃NO₇
• Molecular Weight: 423.507

Synonyms:(4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester

Chemical Property of (4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester

There total 3 articles about (4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + N-Boc-N,O-(2,4-dimethoxybenzylidene)-β-isobutylisoserine sodium salt (675584-92-6) → (4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester (318464-25-4)

Guidance literature:

With 4-methyl-morpholine; dmap; pivaloyl chloride; In tetrahydrofuran; at 20 ℃; for 0.25h;

Reference yield:

(2R,3S)-3-(N-boc)amino-2-hydroxy-5-methylhexanoic acid methyl ester + 2,4-dimethoxybenzaldehyde dimethylacetal (91352-76-0) → (4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester (318464-25-4)

Guidance literature:

With pyridinium p-toluenesulfonate; In tetrahydrofuran; for 14.5h; Heating / reflux;

Reference yield:

methanol (67-56-1) + C21H30ClNO6 (942485-86-1) → (4S,5R)-N-boc-2-(2,4-dimethoxy-phenyl)-4-isobutyl-1-oxazolidine-5-carboxylic acid methyl ester (318464-25-4)

Guidance literature:

upstream raw materials:

2,4-dimethoxybenzaldehyde dimethylacetal

methanol

C₂₁H₃₀ClNO₆

N-Boc-N,O-(2,4-dimethoxybenzylidene)-β-isobutylisoserine sodium salt

Downstream raw materials:

C₄₆H₅₄⁽²⁾H₉NO₁₅

C₂₂H₂₄⁽²⁾H₉NO₇

C₂₁H₂₁⁽²⁾H₉NO₇^(1-)*Na⁽¹⁺⁾

C₅₅H₆₂⁽²⁾H₉NO₁₇

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