<<6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralinyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester

Base Information

Chemical Name:<<6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralinyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester
CAS No.:84802-86-8
Molecular Formula:C₄₆H₅₃N₅O₉
Molecular Weight:819.955
Hs Code.:

Synonyms:<<6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralinyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester

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Chemical Property of <<6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralinyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester

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Technology Process of <<6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralinyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester

There total 4 articles about <<6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralinyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 68709-94-4
glycyl-glycyl-(S)phenylalanyl-(S)leucine methyl ester

: 84802-85-7
6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralincarboxylic acid

: 84802-86-8
<<6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralinyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; for 56h; Ambient temperature;
DOI:10.1021/jm00359a024

Reference yield:

: 100-39-0
benzyl bromide

: 84802-86-8
<<6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralinyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 2N aq. NaOH, CuSO₄, 3.) aq. HCl

2: 1.) 2 N aq. NaOH / 1.) heating, 2.) RT, 60 h

3: 89 percent / Et₃N, 1-hydroxybenzotriazole, DCC / CH₂Cl₂ / 56 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; copper(II) sulfate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm00359a024

Reference yield:

: 84809-70-1
2-amino-6-hydroxy-2-tetralincarboxylic acid

: 84802-86-8
<<6-(benzyloxy)-2-<(benzyloxy)carbamido>-2-tetralinyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 2N aq. NaOH, CuSO₄, 3.) aq. HCl

2: 1.) 2 N aq. NaOH / 1.) heating, 2.) RT, 60 h

3: 89 percent / Et₃N, 1-hydroxybenzotriazole, DCC / CH₂Cl₂ / 56 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; copper(II) sulfate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm00359a024