4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid

Base Information

• Chemical Name: 4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid
• CAS No.: 1343496-03-6
• Molecular Formula: C₂₆H₃₇N₅O₈
• Molecular Weight: 547.608

Synonyms:4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid

Chemical Property of 4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid

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Technology Process of 4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid

There total 2 articles about 4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinic acid (110-15-6) + 2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate (1089216-09-0) → 4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid (1343496-03-6)

Guidance literature:

succinic acid; 2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate; With dmap; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja2069278

Reference yield:

2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid (1089216-06-7) → 4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid (1343496-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: dmap / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With dmap; In dichloromethane;

DOI:10.1021/ja2069278

Reference yield: 87.0%

2-methyl-2-propenoic acid 2-hydroxyethyl ester (868-77-9,141668-69-1,25736-86-1,82601-55-6,25249-16-5) + 4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid (1343496-03-6) → 2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethyl (2-(methacryloyloxy)ethyl) succinate (1343496-04-7)

Guidance literature:

2-methyl-2-propenoic acid 2-hydroxyethyl ester; 4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid; With dmap; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja2069278

upstream raw materials:

2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid

succinic acid

2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate

Downstream raw materials:

2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethyl (2-(methacryloyloxy)ethyl) succinate

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