2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate

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Chemical Name:2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate
CAS No.:1089216-09-0
Molecular Formula:C₂₂H₃₃N₅O₅
Molecular Weight:447.535
Hs Code.:

Synonyms:2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate

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Chemical Property of 2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate

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Technology Process of 2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate

There total 2 articles about 2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1089216-03-4
[2-(3-butylureido)-7-cyclohexanemethyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]-acetic acid ethyl ester

: 107-21-1
ethylene glycol

: 1089216-09-0
2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate

Guidance literature:: With potassium cyanide; at 75 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol802344w

Reference yield:

: 1089216-06-7
2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid

: 107-21-1
ethylene glycol

: 1089216-09-0
2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate

Guidance literature:: 2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid; ethylene glycol; With dmap; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja2069278

Reference yield:

: 110-15-6
succinic acid

: 1089216-09-0
2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate

: 1343496-03-6
4-(2-(2-(2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetoxy)ethoxy)-4-oxobutanoic acid

Guidance literature:: succinic acid; 2-hydroxyethyl-2-[2-(3-butylureido)-7-(cyclohexylmethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl]acetate; With dmap; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja2069278